3D细胞环在医学研究中的应用  

The Application of 3D Cell Ring in Medicine Study

作　　者：吴宏伟[1] 许彦 黄钢[1] 刘珈[1] Wu Hongwei;Xu Yan;Huang Gang;Liu Jia(Hunan Cancer Hospital,Changsha,410013,China)

机构地区：[1]湖南省肿瘤医院,长沙410013

出　　处：《生命科学仪器》2020年第1期26-33,共8页Life Science Instruments

基　　金：长沙市科技平台和人才计划重点项目kh1801129;湖南省自然科学基金2017JJ3109;湖南省科技厅重点研发项目2017DK2012;长沙市科技计划项目kq1706042;国家自然科学基金国家重大科研仪器研制项目8182780017。

摘　　要：3D细胞培养比传统二维培养能更好模拟人体内环境,增加细胞间通讯,还原疾病状态,使生物医学的研究更接近人体真实情况。3D细胞环是一种无支架3D细胞培养结构,具有规则的外形、可夹取便于移植等特点,在生物医学诸多领域都有广泛应用。本文作者结合自身目前已有的工作基础,就3D细胞环在干细胞分化、组织移植和再生、糖尿病治疗、肿瘤研究、药物检测、以及研究热放疗生物学效应、肿瘤动物建模、疾病模型构建等领域的潜在应用做一综述,旨在推动国内3D细胞培养技术的发展,以及促进医学研究由二维向3D模式的跨越。Compared with the traditional two-dimensional culture,three-dimensional cell culture can better simulate the internal environment of human body,increase the communication between cells,restore the disease state,and make the biomedical research closer to the real situation of human body.3D cell ring is a cell free cell culture construct with regular and transplantable 3D structure which has broad application in biomedical research field.In this review,based on the previous work,the author summarized the potential applications of 3D cell ring in stem cell differentiation,tissue transplantation and regeneration,diabetes therapy,tumor research,drug screening,tumor response to thermal and radiotherapy,tumor animal modeling,disease model construction etc.It aims to promote the development of 3D cell culture technology and medical research mode from 2D to 3D in China.

关 键 词：3D细胞培养 组织工程 糖尿病治疗 肿瘤研究 药物检测 

分 类 号：R730.5[医药卫生—肿瘤]