胃炎方对脾胃湿热型慢性萎缩性胃炎的疗效及对患者IFN-β、自由基的影响  

Effect of Weiyan Recipe for Spleen-stomach Damp-heat Type Chronic Atrophic Gastritis and the Change of IFN-β and Free Radical

作　　者：魏家 朱春龙 WEI Jia;ZHU Chunlong(Department of Traditional Chinese Medicine,Zhangjiagang Hospital Affilliated to Suzhou University,Zhangjiagang Jiangsu 215600,China)

机构地区：[1]苏州大学附属张家港医院中医科,江苏张家港215600

出　　处：《四川中医》2020年第3期116-119,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察胃炎方对脾胃湿热型慢性萎缩性胃炎患者的疗效及干扰素-β(IFN-β)、自由基的变化。方法:选取我院(2013年1月~2018年11月)收治的脾胃湿热型慢性萎缩性胃炎患者114例,根据治疗方法不同分为2组。对照组给予常规西药对症治疗,观察组在对照组基础上给予胃炎方治疗,分析2组患者治疗后的临床疗效。结果:2组治疗前中医症状积分组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后胃痞胀痛(1.01±0.22)分、口苦口臭(0.91±0.27)分、恶心或呕吐(0.82±0.21)分、胃脘灼热(0.93±0.22)分、大便黏滞或稀溏(0.63±0.23)分低于对照组(P<0.05)。2组治疗前IFN-β、白细胞介素-23(IL-23)、胃泌素-17(G-17)、自由基水平组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后G-17、超氧化物歧化酶(SOD)水平高于对照组,IFN-β、IL-23、丙二醛(MDA)水平低于对照组(P<0.05)。观察组总有效率为91.23%,对照组为73.68%,观察组患者总有效率高于对照组(P<0.05)。结论:胃炎方治疗脾胃湿热型慢性萎缩性胃炎可改善氧化应激状态,减轻炎症状态,促进G-17的分泌,提高疗效。Objective:To study the efficacy of using Weiyan Recipe in the treatment of chronic atrophic gastritis with spleen-stomach damp-heat type and the changes of interferon-β(IFN-β) and free radicals.Methods:From January 2013 to November 2018,114 patients with chronic atrophic gastritis of spleen and stomach dampness and heat type were divided into two groups according to the different treatment methods.The controlled group was treated with routine western medicine,and the observation group was treated with Weiyan Recipe on the basis of the controlled group.The clinical efficacy of the two groups after treatment was analyzed.Results:There was no significant difference in TCM symptom score between the two groups before treatment(P > 0.05).After treatment,the observation group had(1.01±0.22) points of distension and pain,(0.91±0.27) points of bad breath,(0.82±0.21) points of nausea or vomiting,and(0.93±0.22) points of heartburn.The score of stool viscosity or loose stools(0.63±0.23) was lower than that of the controlled group(P < 0.05).There was no significant difference in the levels of IFN-β,IL-23,G-17 and free radicals between the two groups before treatment(P > 0.05).After treatment,the levels of SOD(SOD) in the observation group were higher than those in the controlled group,while the levels of malondialdehyde(MDA) in IFN-β and IL-23,in the observation group were lower than those in the controlled group(P < 0.05).The total effective rate was 91.23% in the observation group and 73.68% in the controlled group.The total effective rate in the observation group was higher than that in the controlled group(P < 0.05).Conclusion:Weiyan Recipe can improve oxidative stress,reduce inflammatory state,promote the secretion of G-17 and improve the curative effect of chronic atrophic gastritis with dampness and heat of spleen and stomach.

关 键 词：胃炎方 脾胃湿热型 慢性萎缩性胃炎 干扰素-Β 自由基 疗效 

分 类 号：R573.32[医药卫生—消化系统]