自拟清胃汤联合四联疗法治疗Hp感染(脾胃湿热证)疗效观察  

Curative Observation of Using Qingwei Decoction Combined with Quadruple Therapy in the Treatment of HP Infection (Spleen-Stomach Damp-heat Syndrome)

作　　者：张振山[1] 姚天宇[2] 许迪[3] ZHANG Zhenshan;YAO Tianyu;XU Di(Department of Radio-therapy and Chemotherapy,Cangzhou Integrated Chinese and Western Medicine Hospital,Cangzhou Hebei 061001,China;The Three Department of Cardiology,Cangzhou Integrated Chinese and Western Medicine Hospital,Cangzhou Hebei 061001,China;Department of Spleen-Stamoch and Hepatology,Cangzhou Integrated Chinese and Western Medicine Hospital,Cangzhou Hebei 061001,China)

机构地区：[1]河北省沧州中西医结合医院放化疗科,河北沧州061001 [2]河北省沧州中西医结合医院心内三科,河北沧州061001 [3]河北省沧州中西医结合医院脾胃肝病科,河北沧州061001

出　　处：《四川中医》2020年第3期119-122,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：2016年沧州市科学技术研究与发展指导计划(编号:162302180)。

摘　　要：目的:观察中药清胃汤联合四联疗法治疗幽门螺杆菌(Hp)感染(脾胃湿热证)的疗效。方法:将脾胃湿热型98例HP感染患者按照随机数字表法分为2组,每组49例,对照组接受奥美拉唑、阿莫西林、克拉霉素、胶体酒石酸铋四联疗法,观察组在对照组治疗基础上应用中药清胃汤口服,两组均连续治疗2周,停药后1个月进行13C呼气试验检查。比较两组治疗后Hp根除率,比较两组治疗前后中医证候疗效和各单项中医证候疗效。对两组随访12个月,比较两组复发率。结果:两组Hp根除率差异无统计学意义(P>0.05),观察组中医证候疗效优于对照组(P<0.05),单项中医证候中,上腹痞满、胃脘胀痛、口苦咽干、口中异味、恶心呕吐、纳差、嗳气反酸疗效均优于对照组(P<0.05),观察组12个月复发率低于对照组(P<0.05),差异均有统计学意义。结论:自拟中药清胃汤联合四联疗法可改善脾胃湿热型Hp感染患者的中医证候,降低根除后复发率,在HP感染的治疗中具有较高的临床价值。Objective:To explore the therapeutic effect of Qingwei Decoction combined with quadruple therapy on Helicobacter pylori(HP) infection(spleen-stomach damp-heat syndrome).Methods:98 patients with HP infection of(spleen-stomach damp-heat syndrome) were divided into two groups according to the random number table method,with 49 cases in each group.The controlled group received Omeprazole,Amoxicillin,Clarithromycin,Colloidal Bismuth Tartrate quadruple therapy.The observation group were treated with Qingwei Decoction,a traditional Chinese medicine,on the basis of the treatment of the controlled group.The two groups were treated for two consecutive weeks,and the C13 breath test was carried out in one month after the drug was stopped.The HP eradication rate of the two groups before and after treatment was compared,and the curative effect of TCM syndromes before and after treatment and the curative effect of each single TCM syndrome were compared.The two groups were followed up for 12 months and the recurrence rate was compared.Results:There was no significant difference in HP eradication rate between the two groups(P > 0.05).The curative effect of TCM syndrome of the observation group was better than that of the controlled group(P < 0.05).In the single TCM syndrome,the curative effects of epigastric fullness,epigastric distention,stomachache and pharyngeal dryness,peculiar smell in the mouth,nausea and vomiting,poor appetite,belching and acid regurgitation were better than those of the controlled group(P < 0.05).The recurrence rate of 12 months in the observation group was lower than that of the controlled group(P < 0.05).The difference was statistically significant.Conclusion:The combination of Qingwei Decoction and quadruple therapy can improve the TCM syndromes of HP patients with spleen-stomach damp-heat syndrome and reduce the recurrence rate after eradication,which has a high clinical value in the treatment of HP infection.

关 键 词：幽门螺杆菌感染 四联疗法 中药 清胃汤 脾胃湿热 

分 类 号：R573.3[医药卫生—消化系统]