脂肪酸代谢在恶性肿瘤发生机制及分子影像中的应用  

Appliaction of fatty acid metabolism in occurrence and molecular imaging of malignant tumors

作　　者：刘畅 张一帆[1] LIU Chang;ZHANG Yifan(Department of Nuclear Medicine,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院核医学科,上海200025

出　　处：《分子影像学杂志》2020年第1期16-19,共4页Journal of Molecular Imaging

基　　金：国家自然科学基金(81671720,81971644)。

摘　　要：恶性肿瘤的增殖需要多种能量物质包括糖、脂肪和蛋白质。代谢重编程为恶性肿瘤提供能量,促进肿瘤的发生发展。沃伯格效应被认为是肿瘤代谢的主要方式,在这个过程中葡萄糖利用增加,为肿瘤代谢提供能量;利用此特性18F-FDG显像因能准确反应肿瘤生物学特征、位置、进展和对治疗的反应,PET等分子影像已广泛应用于肿瘤诊断和治疗并发挥不可替代作用。此外,肿瘤还需要脂肪酸代谢产物调控蛋白质翻译后修饰,提供脂质信号分子及膜磷脂以抵抗化疗药物的作用等。利用肿瘤细胞脂肪酸合成增加这一特性,放射性核素标记短链脂肪酸可用于肿瘤显像。本文对肿瘤脂肪酸代谢及其分子影像学相关研究做一综述。Malignant proliferation of tumor cells require multiple energy substances, including glucose, fatty acid and protein.Metabolic reprogramming is an important biomarker of cancer which improves the occurrence and development of malignant tumors. The Warburg effect is a key metabolic hallmark of cancer, which significantly increased glucose consumption and provided energy for tumor metabolism. Using this characteristic, 18F-FDG imaging can accurately reflect tumor biological characteristics, location, progress and response to treatment. Molecular imaging such as PET has been widely used in cancer diagnosis and prognosis after treatment. In addition, fatty acid metabolites also regulate the post-translational modifications of protein and provides lipid signal molecule as well as membrane phospholipid to resist the effect of chemotherapeutic drugs.Thus, taking advantage of fatty acid synthesis in tumors, radiolabeled short-chain fatty acid can used for the diagnosis of cancer. This review focuses on the research of fatty acid metabolism and molecular imaging in cancer.

关 键 词：脂肪酸 肿瘤 代谢 放射性核素 分子影像 

分 类 号：R73[医药卫生—肿瘤]