老年抑郁症认知功能与血清同型半胱氨酸及血脂水平的相关性  

Correlation between cognitive function,serum homocysteine and blood lipid levels in elderly patients with depression

作　　者：朱菊红[1] 李菲菲[2] 杨斌[1] 张兰[1] 王欢[1] 范阿娇 Zhu Juhong;Li Feifei;Yang Bin;Zhang Lan;Wang Huan;Fan A Jiao(Department of Psychiatry,the Second Hospital of Lanzhou College,Lanzhou 730000,China;Department of Laboratory, the Second Hospital of Lanzhou College, Lanzhou 730000, China)

机构地区：[1]兰州大学第二医院心理卫生科,甘肃兰州730000 [2]兰州大学第二医院检验科,甘肃兰州730000

出　　处：《临床荟萃》2020年第4期353-356,共4页Clinical Focus

摘　　要：目的研究老年抑郁症患者血清同型半胱氨酸(Hcy)、血脂水平与认知功能之间的关系。方法选取60例老年抑郁患者为研究组,以60例健康志愿者为对照组,测定两组血清Hcy、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平。用汉密尔顿抑郁量表(HAMD)评定病情严重程度,蒙特利尔认知评估量表(MoCA)评估患者的认知功能。结果与对照组比较,研究组MoCA评分明显低于对照组(P<0.05),血清Hcy明显高于对照组(P<0.05),血清HDL-C水平明显低于对照组(P<0.05)。相关分析显示,研究组认知功能损害程度与病情严重程度呈正相关(r=0.327,P<0.01),认知功能评估中注意与集中、记忆、执行功能评分与血清Hcy水平呈负相关(r=-0.402,P=0.01),其中执行功能评分与HDL-C水平成正相关(r=0.562,P=0.008)。结论老年抑郁症患者的认知功能损害与血清高水平Hcy和低水平HDL-C水平有关,血清高水平Hcy和低水平HDL-C可能是老年抑郁症患者的危险因素。Objective To study the relationship between serum homocysteine(Hcy),blood lipid levels and cognitive function in elderly patients with depression.Methods Sixty elderly patients with depression were selected as study group,and 60 healthy volunteers were selected as normal control group.The serum levels of homocysteine(Hcy),total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)were measured in two groups.Hamilton Depression Scale(HAMD)was used to assess the severity of the disease,and Montreal Cognitive Assessment Scale(MoCA)was used to assess the cognitive function of the patients.Results Compared with the normal control group,the MOCA score of study group was significantly lower than that of control group(P<0.05),the serum Hcy was significantly higher than that of control group(P<0.05),and the serum HDL-C level was significantly lower than that of control group(P<0.05).The correlation analysis showed that the degree of cognitive impairment was positively correlated with the severity of the disease in study group(r=0.327,P<0.01).The three dimensions of attention and concentration,memory,executive function scores and serum Hcy levels were negatively correlated in cognitive function assessment(r=-0.402,P=0.01).There was positive correlation between the executive function score and HDL-C level(r=0.562,P=0.008).Conclusion Cognitive impairment of the elderly patients with depression is related to high levels of Hcy and low levels of HDL-C in serum.High levels of Hcy and low levels of HDL-C in serum may be the risk factors for elderly patients with depression.

关 键 词：抑郁症 认知功能 同型半胱氨酸 血脂 

分 类 号：R749.41[医药卫生—神经病学与精神病学]