口腔黏膜癌前病变和口腔癌动物模型的研究进展  

Development of precancerous lesions of oral mucous membrane diseases and oral cancer animal models

作　　者：程俊鑫 白贺天 常治楠 李敬[1] 陈谦明[1] Cheng Junxin;Bai Hetian;Chang Zhinan;Li Jing;Chen Qianming(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院,成都610041

出　　处：《华西口腔医学杂志》2020年第2期198-204,共7页West China Journal of Stomatology

基　　金：国家重点研发计划重点专项课题(2017YFC0840100,2017YFC0840107);国家自然科学基金(81872211,81672675,81621062);高等学校学科创新引智计划(111计划)(B14038);四川大学大学生创新创意实验项目(20171082,20171083)。

摘　　要：口腔黏膜癌前病变和口腔癌是发展中国家的常见疾病尤其是在南亚地区,其癌变机制尚不明确,目前缺乏有效防治措施,因此口腔黏膜癌前病变及口腔癌动物模型建立显得尤为重要。本文结合相关研究,就近年来口腔黏膜癌前病变及口腔癌动物模型建立方法的进展作一综述。Precancerous lesions of oral mucous membrane diseases and oral cancer are common diseases in developing countries,especially in South Asia.However,the cancerous mechanism remains unclear,and no efficient treatment and prognosis measure are currently available.Thus,precancerous lesions of the oral mucosa and oral cancer animal models must be identified to further understand their function.In this paper,we systematically review the development of oral mucosal precancerous lesions and oral cancer animal models by referring to related research.

关 键 词：口腔黏膜癌前病变 口腔癌 动物模型 

分 类 号：R78[医药卫生—口腔医学]