卵母细胞衰老的分子病因学研究进展  

Advances in research on molecular etiology of oocyte aging

作　　者：李岩 刘珏[1] 刘民[1] LI Yan;LIU Jue;LIU Min(Department of Epidemiology&Biostatistics,School of Public Health,Peking University,Beijing 100191;Department of Epidemiology,Beijing An Zhen Hospital,Capital Medical University/Beijing Institute of Heart,Lung&Blood Vessel Diseases,Beijing 100029)

机构地区：[1]北京大学公共卫生学院流行病与卫生统计学系,北京100191 [2]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所流行病研究室,北京100029

出　　处：《生殖医学杂志》2020年第4期555-559,共5页Journal of Reproductive Medicine

基　　金：国家自然科学基金(71874003,81703240,71934002);北京市自然科学基金(5172011)。

摘　　要：卵母细胞衰老是女性自然衰老的开始,在分子层面了解导致卵母细胞衰老的原因和机制,对于抑制与年龄相关的疾病和促进女性健康长寿至关重要。本文对卵母细胞衰老的分子病因机制,从基因组的完整性和稳定性、线粒体功能障碍、端粒缩短、DNA损伤修复、表观遗传学改变、以及神经内分泌级联反应等几个方面展开详细综述。Oocyte aging is beginning of natural aging of women.Understanding the causes and mechanisms of oocyte aging at the molecular level is essential for controlling age-related diseases and promoting healthy and long life of women.This paper reviews the molecular pathogenesis of oocyte aging in detail from the aspects of genome integrity and stability,mitochondrial dysfunction,telomere shortening,DNA damage repair,epigenetic changes,and neuroendocrine cascade reaction.

关 键 词：卵母细胞衰老 表观遗传学 分子病因学 

分 类 号：R711[医药卫生—妇产科学]