不可逆电穿孔技术联合导管电极用于组织消融的研究进展  

Research Progress of Catheter-based Irreversible Electroporation for Tissue Ablation

作　　者：周一坤 韩轩 任冯刚[1,2,4] 李青山[1,2,4] 陈雪 初大可 吴荣谦[1,2] 吕毅[1,2,4] ZHOU Yikun;HAN Xuan;REN Fenggang;LI Qingshan;CHEN Xue;CHU Dake;WU Rongqian;LYU Yi(National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine,First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,710061;Regenerative Medicine and Surgical Engineering Research Center of Shaanxi Province,First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,710061;Zonglian College of Xi'an Jiaotong University,Xi'an,710061;Department of Hepatobiliary Surgery,First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,710061;Department of Gastroenterology,First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,710061)

机构地区：[1]西安交通大学第一附属医院精准外科与再生医学国家地方联合工程研究中心,西安市710061 [2]西安交通大学第一附属医院陕西省再生医学与外科工程研究中心,西安市710061 [3]西安交通大学宗濂书院,西安市710061 [4]西安交通大学第一附属医院肝胆外科,西安市710061 [5]西安交通大学第一附属医院消化内科,西安市710061

出　　处：《中国医疗器械杂志》2020年第2期172-178,共7页Chinese Journal of Medical Instrumentation

基　　金：国家自然科学基金重大科研仪器研制项目(81727802);国家重点研发计划“数字诊疗装备研发”重点专项(2018YFC0115305);中央高校基本科研业务费(SXJH012019076)。

摘　　要：不可逆电穿孔是一种新兴的组织物理消融技术。相较于射频等热消融技术,不可逆电穿孔表现出消融时间短,不受热沉效应影响、不损伤组织支架结构等特点,在肝癌、胰腺癌和前列腺癌等肿瘤的治疗中表现出良好效果。近年来,国内外多个团队致力于不可逆电穿孔联合导管电极用于消化道、支气管、泌尿道和心肌组织消融的研究,初步证实内镜或介入技术下不可逆电穿孔用于管腔组织消融的安全性与有效性。该研究团队综述了不可逆电穿孔联合导管电极用于组织消融的研究进展,并对其关键技术与未来发展方向进行了展望。Irreversible electroporation(IRE) is an emerging tissue ablation technique. Compared with thermal ablation technique such as radiofrequency, IRE can achieve focal ablation in a shorter time without heat sink effect while sparing the tissue scaffold. IRE has been demonstrated to be a feasible therapeutic modality for the liver, pancreatic, and prostatic cancer. In recent years, several studies regarding of catheter-directed IRE for digestive tract, bronchus, urinary tract, and myocardium have been performed, which preliminarily demonstrated the safety and efficacy of IRE for tissue ablation under endoscopic or interventional technique. This study summarized the research progress of catheter-directed IRE for tissue ablation. The critical technique and future direction of catheter-based IRE are prospected as well.

关 键 词：不可逆电穿孔 导管电极 内镜 介入 

分 类 号：R730.5[医药卫生—肿瘤]