Review of the diagnosis of gastrointestinal lanthanum deposition  

作　　者：Masaya Iwamuro Haruo Urata Takehiro Tanaka Hiroyuki Okada 

机构地区：[1]Department of Gastroenterology and Hepatology,Okayama University Graduate School of Medicine,Dentistry,and Pharmaceutical Sciences,Okayama 7008558,Japan [2]Central Research Laboratory,Okayama University Medical School,Okayama 7008558,Japan [3]Department of Pathology,Okayama University Hospital,Okayama 7008558,Japan

出　　处：《World Journal of Gastroenterology》2020年第13期1439-1449,共11页世界胃肠病学杂志（英文版）

摘　　要：Lanthanum carbonate is used for treatment of hyperphosphatemia mostly in patients with chronic renal failure.Although lanthanum carbonate is safe,recently,lanthanum deposition in the gastrointestinal mucosa of patients has been reported in the literature.This review provides an overview of gastroduodenal lanthanum deposition and focuses on disease's endoscopic,radiological,and histological features,prevalence,and outcome,by reviewing relevant clinical studies,case reports,and basic research findings,to better understand the endoscopic manifestation of gastrointestinal lanthanum deposition.The possible relationship between gastric lanthanum deposition pattern and gastric mucosal atrophy is also illustrated;in patients without gastric mucosal atrophy,gastric lanthanum deposition appears as diffuse white lesions in the posterior wall and lesser curvature of the gastric body.In the gastric mucosa with atrophy,lanthanum-related lesions likely appear as annular or granular whitish lesions.Moreover,these white lesions are probably more frequently observed in the lower part of the stomach,where intestinal metaplasia begins.

关 键 词：LANTHANUM CARBONATE HYPERPHOSPHATEMIA GASTROINTESTINAL endoscopy LANTHANUM phosphate Scanning electron microscopy Energy-dispersive X-ray SPECTROMETRY 

分 类 号：R57[医药卫生—消化系统]