术前血清铁蛋白水平在评价食管鳞癌患者预后中的价值  

Prognostic value of preoperative serum ferritin in patients with esophageal squamous cell carcinoma

作　　者：李娜 黄显聪 陈忠坚 高赟[3] 毛伟敏 Li Na;Huang Xiancong;Chen Zhongjian;Gao Yun;Mao Weimin(The Second Clinical Medical College,Zhejiang Chinese Medical University,Hangzhou 310053,China;Department of Thoracic Surgery,Cancer Hospital of the University of Chinese Academy of Sciences,Hangzhou 310022,China;Institute of Cancer and Basic Medicine,Chinese A Cademy of Sciences,Hangzhou 310022,China)

机构地区：[1]浙江中医药大学第二临床医学院,杭州310053 [2]中国科学院大学附属肿瘤医院胸外科,杭州310022 [3]中国科学院肿瘤与基础医学研究所,杭州310022

出　　处：《中华普通外科杂志》2020年第3期211-214,共4页Chinese Journal of General Surgery

基　　金：国家自然科学基金(81672315)。

摘　　要：目的探讨术前血清铁蛋白(SF)水平对食管鳞癌(ESCC)患者预后的评估价值。方法回顾性分析2008年1月至2013年12月于浙江省肿瘤医院行食管癌根治术280例ESCC患者的临床资料,采用单因素分析和Logistic多因素分析术前SF水平与ESCC患者的临床病理特征及预后的关系。结果280例ESCC患者中,低SF组共183例(65.4%),高SF组共97例(34.6%)。低SF组患者的1、3、5年生存率分别为78.7%、50.3%、43.2%,高SF组患者的1、3、5年生存率分别为69.1%、35.1%、32.0%,两组比较差异具有统计学意义(χ^2=4.697,P=0.031)。单因素分析结果显示:脉管瘤栓、神经侵犯、术前SF水平与ESCC患者的预后均有关(均P<0.05)。多因素分析结果显示:脉管瘤栓(OR=1.662,95%CI:1.239~2.229,P=0.001)、神经侵犯(OR=1.823,95%CI:1.361~2.443,P<0.001)、术前SF水平(OR=1.504,95%CI:1.113~2.032,P=0.008)均是影响ESCC患者预后的独立危险因素。结论术前高SF水平ESCC患者的预后较差;术前SF水平是影响ESCC患者预后的独立危险因素。Objective To evaluate preoperative serum ferritin(SF)in predicting the prognosis of patients with esophageal squamous cell carcinoma(ESCC).Methods A retrospective analysis was conducted on 280 ESCC patients undergoing radical resection of esophageal cancer at Zhejiang Cancer Hospital from Jan 2008 to Dec 2013.Univariate and multivariate analysis were used to investigate the relationship between preoperative SF level and patients′clinicopathologic characteristics.Kaplain-Meier method was used to analyze the relationship between preoperative SF level and the prognosis.Results There were 183 cases(65.4%)with low SF level and 97cases(34.6%)with high SF level.The 1-,3-and 5-year survival rates in low SF patients were 78.7%,50.3%,43.2%and that in high SF were 69.1%,35.1%,32.0%,respectively(χ^2=4.697,P=0.031).Univariate analysis demonstrated that intravascular cancer embolus,nerve infiltration and the level of preoperative SF were related to ESCC patients prognosis(all P<0.05).The multivariate analysis showed that carcinoma cell embolus(OR=1.662,95%CI:1.239-2.229,P=0.001),nerve infiltration(OR=1.823,95%CI:1.361-2.443,P<0.001)and the level of preoperative SF(OR=1.504,95%CI:1.113-2.032,P=0.008)were independent risk factors for ESCC patients prognosis.Conclusion Preoperative SF level closely associates with the prognosis of ESCC patients.

关 键 词：食管肿瘤 铁蛋白质类 预后 

分 类 号：R735[医药卫生—肿瘤]