肿瘤预转移微环境形成的研究进展  

Research Advances on Tumor Pre-Metastatic Niche

作　　者：张伟浩 杨丹丹 姜浩[1] 杨建明 郁雷[1] 高峰[2] ZHANG Wei-hao;YANG Dan-dan;JIANG Hao;YANG Jian-ming;YU Lei;GAO Feng(The Second Affiliated Hospital of Harbin Medical University,Harbin 150000,China)

机构地区：[1]哈尔滨医科大学附属第二医院,黑龙江哈尔滨150000 [2]哈尔滨医科大学附属第二医院结直肠肿瘤外科,黑龙江哈尔滨150000

出　　处：《肿瘤学杂志》2020年第3期224-228,共5页Journal of Chinese Oncology

基　　金：哈尔滨市科技创新人才(2015RAQYJ103);吴阶平医学基金会(320.6750.18492)。

摘　　要：原发灶肿瘤通过诱导并改造未来转移器官,使之成为适合循环肿瘤细胞(circulatingtumor cells,CTCs)定植的微环境,即肿瘤预转移微环境(pre-metastatic niche,PMN)。PMN形成包括血管渗漏及通透性改变、凝血异常、细胞外基质重塑、骨髓源细胞的迁移和募集、免疫抑制等过程,其中肿瘤来源外泌体,肿瘤来源可溶性因子(tumor-derived soluble factors,TDSFs),骨髓源细胞(bone marrow-derived cells,BMDCs)等在这过程中至关重要。全文结合国内外最新研究成果,对外泌体、TDSFs、BMDCs等在PMN形成过程中发挥的作用进行综述,探讨其涉及的具体机制以及可能发现针对肿瘤转移治疗的新靶点和可能面临的挑战。Primary tumors induce and transform future metastatic organs,making them a microenvironment suitable for colonization of circulating tumor cells(CTCs),i.e.pre-metastatic niche(PMN).The formation of PMN includes vascular leakage and permeability changes,abnormal blood coagulation,extracellular matrix remodeling,migration and recruitment of bone marrow-derived cells,and immunosuppression,among which tumor-derived exosomes,tumor-derived soluble factors(TDSFs),bone marrow-derived cells(BMDCs)are crucial.This article the role of exosomes,TDSFs and BMDCs in the formation of PMN,and the specific mechanisms involved are reviewed,and possible novel therapeutic targets for tumor metastasis are also explored.

关 键 词：肿瘤转移 预转移微环境 外泌体 骨髓来源细胞 肿瘤来源可溶性因子 

分 类 号：R730.231[医药卫生—肿瘤]