维生素D及其受体与子宫内膜癌的相关研究进展  

Research Progress in the Relationship between Vitamin D and Its Receptor and Endometrial Cancer

作　　者：刘思思 孙振杰 冯文(审校) LIU Si-si;SUN Zhen-jie;FENG Wen(The Affiliated Lianyungang Hospital of Xuzhou Medical University,Lianyungang 222000,Jiangsu Province,China)

机构地区：[1]徐州医科大学附属连云港医院,江苏省连云港市222000

出　　处：《国际妇产科学杂志》2020年第2期129-133,共5页Journal of International Obstetrics and Gynecology

基　　金：江苏省妇幼健康科研课题基金资助项目(F201669)。

摘　　要：维生素D作为脂溶性类固醇衍生物,在生理上具有维持骨质钙磷代谢平衡的功能,有研究显示在免疫系统、内分泌系统、心血管系统疾病及部分肿瘤、炎症发生发展中维生素D发挥促细胞分化、凋亡的作用。维生素D主要通过调节维生素D受体的表达介导靶基因转录过程,实现抗肿瘤的生物学效应。近年来有研究发现在子宫内膜癌组织中存在维生素D受体的表达,提示其可能与子宫内膜癌进展有关,可能是子宫内膜癌治疗的潜在靶点。随着对抗肿瘤机制的深入探索,维生素D及其类似物被用于肿瘤内分泌治疗。综述维生素D受体生物学基础、维生素D抗肿瘤作用及其在子宫内膜癌中应用的相关研究。As a fat-soluble steroid derivative,vitamin D has the physiological function of maintaining the balance of calcium and phosphorus metabolism of bone.Some studies have shown that vitamin D can promote the process of cell differentiation and apoptosis in the development of diseases of the immune system,endocrine system,cardiovascular system,some tumors and inflammation.Vitamin D mainly regulates the expression of vitamin D receptor,mediates the transcription of target genes,and realizes the biological effect of anti-tumor.In recent years,some studies have found the expression of vitamin D receptor in endometrial cancer tissues,suggesting that it may be related to the progression of endometrial cancer and may be a potential target for the treatment of endometrial cancer.Vitamin D and its analogues have been used in endocrine therapy for cancer as the mechanism of anti-tumor therapy has been further explored.The biological basis of vitamin D receptor,the antitumor effect of vitamin D and its application in endometrial cancer were reviewed.

关 键 词：子宫内膜肿瘤 维生素D 受体 骨化三醇 肿瘤形成过程 

分 类 号：R737.33[医药卫生—肿瘤]