妊娠期高血压疾病胎盘浅着床的研究进展  

Research Progress on Superficial Placental Implantation of Hypertensive Disorders of Pregnancy

作　　者：王卉菲 郭宇婧 王敏[1] 马帅 刘艺 贾赞慧(审校)[1] WANG Hui-fei;GUO Yu-jing;WANG Min;MA Shuai;LIU Yi;JIA Zan-hui(The Second Hospital of Jilin University,Changchun 130000,China)

机构地区：[1]吉林大学第二医院,长春130000

出　　处：《国际妇产科学杂志》2020年第2期165-168,共4页Journal of International Obstetrics and Gynecology

摘　　要：妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)是妊娠期特发性疾病,严重影响母婴健康,是孕产妇和围生儿死亡率升高的主要原因,但其确切病因及发病机制仍不清楚。近年发现,胎盘浅着床是HDP发病的重要机制,影响胎盘浅着床过程的因素可分为3个方面:一是影响滋养细胞侵袭能力,主要包括缺氧、细胞因子、表观遗传调控等;二是影响炎症因子浸润过程,包括趋化因子家族及蜕膜自然杀伤细胞等;三是影响细胞外基质降解的程度,主要包括基质金属蛋白酶(MMPs)及其相关的影响因素等。综述HDP胎盘浅着床的发生机制,以期为临床疾病早期诊断、治疗及预防提供一个新的方向。Hypertensive disorders of pregnancy(HDP)is an idiopathic disease of pregnancy,which seriously impact maternal and fetal health.It is a major cause of maternal and perinatal mortality,but its exact etiology and pathogenesis are still unclear.In recent years,it has been found that shallow implantation of placenta is an important mechanism of HDP.The factors influencing the process of shallow implantation of placenta can be divided into three aspects.The first is to affect the invasion ability of traphoblasts,mainly including hypoxia,cytokines,epigenetic regulation.The second is to influence the infiltration process of inflammatory factors,including chemokine family and decidual natural killer cells.The third is the degree of degradation of extracellular matrix,mainly including matrix metalloproteinases(MMPs)and related influencing factors.The mechanism of placental shallow implantation of HDP was reviewed in order to provide a new direction for early diagnosis,treatment and prevention of clinical diseases.

关 键 词：高血压 妊娠性 胎盘 胚胎植入 胎盘功能不全 滋养层 

分 类 号：R714.246[医药卫生—妇产科学]