熊去氧胆酸辅助铝碳酸镁治疗胆汁反流性胃炎的可行性及安全性分析  

Analysis on feasibility and safety of ursodeoxycholic acid assisted aluminum carbonic acid magnesium in treatment of bile reflux gastritis

作　　者：钟海彬[1] ZHONG Haibin(Second Departmentof Internal Medicine,Wuhua County Hospital of Traditional Chinese Medicine,Guangdong,Wuhua 514400,China)

机构地区：[1]广东省五华县中医医院内科二区,广东五华514400

出　　处：《中国医药科学》2020年第5期90-93,共4页China Medicine And Pharmacy

摘　　要：目的研究熊去氧胆酸辅助铝碳酸镁治疗胆汁反流性胃炎的可行性及安全性。方法选取2017年7月~2018年1月于我院就诊的胆汁反流性胃炎患者76例,采用随机数字表法分为对照组和观察组,每组38例。对照组患者给予埃索美拉唑肠溶片、莫沙必利联合口服治疗,观察组患者在此基础上加用熊去氧胆酸辅助铝碳酸镁治疗,疗程均为2个月。观察两组患者的临床疗效、症状改善情况、胃内24h胆汁反流情况及不良反应发生情况。结果两组患者临床疗效差异有统计学意义(Z=-2.087,P=0.037),观察组治疗有效率显著高于对照组(94.74%vs 71.05%)(χ^2=4.547,P=0.039);治疗后两组患者恶心、呕吐、上腹痛、腹胀各项症状积分均显著降低,且观察组显著低于对照组,差异有统计学意义(P<0.05);观察组经治疗后胃24h胆汁反流总时间短于对照组,反流次数及反流时间持续>5min次数均少于对照组,差异有统计学意义(P<0.05);观察组与对照组不良反应发生率差异无统计学意义(21.05%vs 23.68%)(χ^2=0.076,P=0.783)。结论熊去氧胆酸辅助铝碳酸镁治疗胆汁反流性胃炎具有较高的临床疗效,同时可显著改善临床症状及胆汁反流情况,且不良反应发生较少,具有较高的可行性和安全性,值得临床推广。Objective To study the feasibility and safety of ursodeoxycholic acid assisted aluminum carbonic acid magnesium in treatment of bile reflux gastritis.Methods 76 patients with bile reflux gastritis who were treated in our hospital from July 2017 to January 2018 were selected and they were divided into the control group and the observation group according to the random number table method,with 38 cases in each group.Patients in the control group were given oral administration of esomeprazole enteric-coated tabletscombined withmosapride.Patients in the observation group were given ursodeoxycholic acid assisted hydrotalcite on the basis of the control group.The course of treatment was 2 months.The clinical curative effects,improvement of symptoms,bile reflux within 24 hours and adverse reactions of patients in two groups were observed.Results There were significant differences in clinical curative effects between the two groups(Z=-2.087,P=0.037).The effective rate of treatment in the observation group was significantly higher than that of the control group(94.74%vs 71.05%)(χ^2=4.547,P=0.039).After treatment,the scores of nausea,vomiting,upper abdominal pain and abdominal distention of the two groups were significantly reducedand the score in the observation group was significantly lower than those of the control group.The differences were statistically significant(P<0.05).The total time of gastric bile reflux 24 hours after treatment in the observation group was shorter than that in the control group,the frequency of reflux and frequency of refluxlasting more than 5 minutes were less than those in the control group.The differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group(21.05%vs 23.68%)(χ^2=0.076,P=0.783).Conclusion Ursodeoxycholic acid assisted aluminum carbonic acid magnesiumin treatment of bile reflux gastritis has higher clinical curative effects,which can significantly impr

关 键 词：熊去氧胆酸 铝碳酸镁 胆汁反流性胃炎 不良反应 

分 类 号：R573.3[医药卫生—消化系统]