Recent advances in asymmetric synthesis of 2-substituted indoline derivatives  

作　　者：Ting-Bi Hua Cong Xiao Qing-Qing Yang Jia-Rong Chen 

机构地区：[1]College of Materials and Chemical Engineering,Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials,China Three Gorges University,Yichang 443002,China [2]CCNU-uOttawa Joint Research Centre,Key Laboratory of Pesticides&Chemical Biology Ministry of Education.College of Chemistry,Central China Normal University,Wuhan 430079,China

出　　处：《Chinese Chemical Letters》2020年第2期311-323,共13页中国化学快报（英文版）

基　　金：National Natural Science Foundation of China(Nos.21702121,91856119 and 21622201);the Science and Technology Department of Hubei Province(Nos.2016CFA050 and 2017AHB047);the Program of Introducing Talents of Discipline to Universities of China(111 Program,No.B17019)。

摘　　要：Enantiomerically pure 2-substituted indolines are an important class of nitrogen heterocycles that occur frequently in many alkaloid natural products and biologically active compounds.Consequently,the synthesis of such skeletons is of great significance.The past years have witnessed a number of remarkable advances in the development of efficient strategies to construct this class of chiral compounds.This review summarizes the recent advances in asymmetric synthesis of 2-substituted indoline derivatives.Due to the limitation of the length,this review only summarizes those works published from January of 2012 to January of 2019.Meanwhile,methods towards synthesis of fu sed and spirocyclic indolines will not be discussed in this review.Enantiomerically pure 2-substituted indolines are an important class of nitrogen heterocycles that occur frequently in many alkaloid natural products and biologically active compounds.Consequently,the synthesis of such skeletons is of great significance.The past years have witnessed a number of remarkable advances in the development of efficient strategies to construct this class of chiral compounds.This review summarizes the recent advances in asymmetric synthesis of 2-substituted indoline derivatives.Due to the limitation of the length,this review only summarizes those works published from January of 2012 to January of 2019.Meanwhile,methods towards synthesis of fu sed and spirocyclic indolines will not be discussed in this review.

关 键 词：INDOLINES ASYMMETRIC synthesis ENANTIOSELECTIVITY Nitrogen HETEROCYCLES Synthetic methods 

分 类 号：O626.1[理学—有机化学]