Euphoractone,a cytotoxic meroterpenoid with an unusual entabietane-phloroglucinol skeleton,from Euphorbia fischeriana Steud.  

作　　者：Rihan Xie Linsheng Li Xiaona Fan Jiachen Zi 

机构地区：[1]College of Pharmacy,Ji'nan University,Guangzhou 510632,China [2]School of Medicine,Ji'nan University,Guangzhou 510632,China

出　　处：《Chinese Chemical Letters》2020年第2期431-433,共3页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(No.81673530);Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(No.2017BT01Y036)。

摘　　要：A novel meroterpenoid,euphoractone(1),was isolated from the extracts of the roots of Euphorbia fischeriana Steud.Its structure was determined by spectroscopic methods and X-ray crystallography.1 possesses an unusual ent-abietane-phloroglucinol skeleton.The plausible biosynthetic pathway for 1 was proposed.1 showed inhibitory activities against human lung cancer H23 and H460 cells with the IC_(50)values of 21.07±3.54 and 20.91±4.07 μmol/L.A novel meroterpenoid,euphoractone（1）,was isolated from the extracts of the roots of Euphorbia fischeriana Steud.Its structure was determined by spectroscopic methods and X-ray crystallography.1 possesses an unusual ent-abietane-phloroglucinol skeleton.The plausible biosynthetic pathway for 1 was proposed.1 showed inhibitory activities against human lung cancer H23 and H460 cells with the IC50values of 21.07±3.54 and 20.91±4.07 μmol/L.

关 键 词：EUPHORBIA fischeriana Meroterpenoid ent-Abietane PHLOROGLUCINOL Euphoractone Cytotoxicity 

分 类 号：R284[医药卫生—中药学]