A fast and colorimetric sensor array for the discrimination of ribonucleotides in human urine samples by gold nanorods  

作　　者：Dan Yuan Huihong Yan Jiahui Liu Jiajun Liu Chunmei Li Jian Wang 

机构地区：[1]Key Laboratory of Luminescent and Real-Time Analytical Chemistry(Southwest University),Ministry of Education,College of Pharmaceutical Sciences,Southwest University,Chongqing 400715,China

出　　处：《Chinese Chemical Letters》2020年第2期455-458,共4页中国化学快报（英文版）

基　　金：Natural Science Foundation Project of China(No.21405123);Fundamental Research Funds for the Central Universities(No.XDJK2019AC002)for the financial support。

摘　　要：Ribonucleotides are usually functioned as biomarkers to diagnose diseases and monitor the life activities in living organisms,and their discrimination is of great significance but challenging.Taking advantage of the unique characteristics of gold nanorods(AuNRs),herein,a colorimetric sensor array for discrimination of twelve ribonucleotides was developed based on the chemical etching of AuNRs with controllable aspect ratios.During the etching process,AuNRs were preferentially shortened and eventually turned into Au(Ⅲ) state by Fenton's reaction.The morphological change of AuNRs led to the significant color change and blue shift in the corresponding extinction spectrum.However,when Fe^(2+)bound with ribonucleotides,the Fenton's reaction was prevented and the ability to etch AuNRs was weakened or disappeared.Due to the different structures of nucleotides,the binding ability of them with Fe^(2+) was distinct,resulting in the discrepancy in the chemical etching of AuNRs,which could be developed for distinguishing ribonucleotides.Moreover,the proposed sensor array was successfully explored to distinguish ribonucleotides in complex human urine samples.Ribonucleotides are usually functioned as biomarkers to diagnose diseases and monitor the life activities in living organisms,and their discrimination is of great significance but challenging.Taking advantage of the unique characteristics of gold nanorods（AuNRs）,herein,a colorimetric sensor array for discrimination of twelve ribonucleotides was developed based on the chemical etching of AuNRs with controllable aspect ratios.During the etching process,AuNRs were preferentially shortened and eventually turned into Au（Ⅲ） state by Fenton’s reaction.The morphological change of AuNRs led to the significant color change and blue shift in the corresponding extinction spectrum.However,when Fe2+bound with ribonucleotides,the Fenton’s reaction was prevented and the ability to etch AuNRs was weakened or disappeared.Due to the different structures of nucleotides,the binding ability of them with Fe2+ was distinct,resulting in the discrepancy in the chemical etching of AuNRs,which could be developed for distinguishing ribonucleotides.Moreover,the proposed sensor array was successfully explored to distinguish ribonucleotides in complex human urine samples.

关 键 词：GOLD NANORODS RIBONUCLEOTIDES Chemical ETCHING Principal component analysis Sensor array 

分 类 号：O657.3[理学—分析化学] R446.1[理学—化学]