Tunable morphologies of polymer capsules templated from cuprous oxide particles for control over cell association  

作　　者：Hongyan Pei Yanyan Bai Jianman Guo Zhiliang Gao Qiong Dai Qun Yu Jiwei Cui 

机构地区：[1]Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education,School of Chemistry and Chemical Engineering,Shandong University,Ji'nan 250100,China

出　　处：《Chinese Chemical Letters》2020年第2期505-508,共4页中国化学快报（英文版）

基　　金：financially supported by research general programs from the National Natural Science Foundation of China(Nos.21603120,21872085);Fundamental Research Funding of Shandong University(No.2017JC003)。

摘　　要：Over the past two decades,layer-by-layer(LbL) assembly of micro/nanocapsules has been of interest for the investigation of bio-nano interactions to explore bio-applications,such as drug delivery.The choice of an appropriate template that can be easily dissolved under mild conditions is one of the challenges for the assembly of LbL capsules.Herein,we report the engineering of LbL capsules with tunable morphologies using cuprous oxide(Cu_2O) particles as templates.Cu_2O particles with cubic,tetradecahedral or spherical morphologies were synthesized via hydrothermal processes,which can be dissolved under mild condition(e.g.,sodium thiosulfate solution).The influence of capsule morphologies on cell association was investigated,which indicates that LbL capsules with cubic geometry promoted cell association up to 4 and 9-fold than tetradecahedral and spherical capsules,respectively.The reported method provides a new avenue for the assembly of LbL capsules with different morphologies,which has the potential for better understanding of biological interactions of LbL capsules.Over the past two decades,layer-by-layer（LbL） assembly of micro/nanocapsules has been of interest for the investigation of bio-nano interactions to explore bio-applications,such as drug delivery.The choice of an appropriate template that can be easily dissolved under mild conditions is one of the challenges for the assembly of LbL capsules.Herein,we report the engineering of LbL capsules with tunable morphologies using cuprous oxide（Cu2O） particles as templates.Cu2O particles with cubic,tetradecahedral or spherical morphologies were synthesized via hydrothermal processes,which can be dissolved under mild condition（e.g.,sodium thiosulfate solution）.The influence of capsule morphologies on cell association was investigated,which indicates that LbL capsules with cubic geometry promoted cell association up to 4 and 9-fold than tetradecahedral and spherical capsules,respectively.The reported method provides a new avenue for the assembly of LbL capsules with different morphologies,which has the potential for better understanding of biological interactions of LbL capsules.

关 键 词：Layer-by-layer Cuprous OXIDE Polymer CAPSULES Cell ASSOCIATION POLYPHENOL 

分 类 号：TQ460.4[化学工程—制药化工] TQ317