AD细胞模型的建立及评价方法研究进展  

Research progress on establishment and evaluation methods of AD cellular models

作　　者：邓婷[1] 余志杰 徐颖[1] 李劲松[2] 孙涛[1] DENG Ting;YU Zhi-jie;XU Ying;LI Jin-song;SUN Tao(Chengdu University of Traditional Chinese Medicine,Key Lab of Standardization for Chinese Herbal Medicine, Ministry of Education,Key Lab of Distinctive Chinese Medicine Resources in Southwest China,Chengdu 611137,China;Dept of Rehabilitation,the First People’s Hospital of Guangyuan City,Guangyuan Sichuan 628017,China)

机构地区：[1]成都中医药大学中药材标准化教育部重点实验室西南特色中药资源国家重点实验室,四川成都611137 [2]广元市第一人民医院,四川广元628017

出　　处：《中国药理学通报》2020年第4期470-475,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金面上项目(No 81773906);四川省教育厅重点项目(No 17ZA0152;18ZA0179);四川省中医药管理局项目(No 2016Q053);广元市科技局科技支撑计划项目(No 14KJZCS003)。

摘　　要：细胞模型是研究阿尔茨海默病(Alzheimer’s disease,AD)的有效方法之一。近年来,建立体外AD细胞模型来模拟AD的发病机制已成为学者的关注点。该文通过整理近年AD细胞建模的相关文献,深入探讨AD的发病机制,总结并系统分析AD细胞模型建立方法、评价指标及模型特点,以期对AD细胞模型合理构建及深入研究提供思路与借鉴。Cellular model is one of the effective methods for studying Alzheimer’s disease(AD).In recent years,the establish-ment of AD cellular model to simulate the pathogenesis of AD has become the focus of scholars.By sorting out the relevant literature of AD cellular models in recent years and further exploring pathogenesis of AD,this paper summarizes and systematically analyzes the establishment methods,evaluation indices and model characteristics of AD cellular models,in order to provide ideas and reference for the rational construction and in-depth study of AD cellular models.

关 键 词：阿尔茨海默病 细胞模型 建模 评价方法 模型特点 研究进展 

分 类 号：R-5[医药卫生] R329.24