人源性肝癌组织移植模型研究进展  

Research progress of hepatocellular carcioma patient-derived human tumor xenograft models

作　　者：刘世芳 李宜航[1,2] 陈德力 苏晶[1,2] 吕亚娜 丁璇[1,2] 李光 孙晓波 LIU Shi-fang;LI Yi-hang;CHEN De-li;SU Jing;LYU Ya-na;DING Xuan;LI Guang;SUN Xiao-bo(Pharmacological Center of Yunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College,Jinghong Yunnan 666100, China;Key Labof Dai and Southern Medicine of Xishuangbanna Dai Autonomous Prefecture, Jinghong Yunnan 666100, China;Phytochemical Center of Hainan Branch,Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Haikou570311, China;Pharmacology and Toxicology Center,Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100093, China)

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所云南分所药理中心,云南景洪666100 [2]西双版纳州傣药南药重点实验室,云南景洪666100 [3]中国医学科学院北京协和医学院药用植物研究所海南分所植物化学中心,海南海口570311 [4]中国医学科学院北京协和医学院药用植物研究所药理毒理中心,北京100093

出　　处：《中国药理学通报》2020年第4期475-478,共4页Chinese Pharmacological Bulletin

基　　金：中国医学科学院医学与健康科技创新工程经费(No 2016-I2M-1-012);国家自然科学基金资助项目(No 81503289);云南省基础研究面上项目(No 2016FB143);云南省技术创新人才培养项目(No 2017HB097)。

摘　　要：人源性肿瘤组织移植(Patient-derived human tumor xenograft,PDX)模型能很好的保持原代肿瘤的组织病理学、生长及转移特性,并在多次传代后仍然能够在较大程度上保留原代肿瘤的这些特性,与原始患者肿瘤密切相关,具有重要科研价值。肝癌PDX模型已用于患者的个性化药物筛选、药物疗效的评价、治疗方向的探索、肝癌的发生发展机制等,具有良好的应用前景。该文对肝癌PDX模型的方法、应用以及成瘤因素等方面进行综述。Patient-derived human tumor xenograft(PDX)models can maintain the histopathological,growth and metastasis characteristics of primary tumors well,and can still retain these characteristics of primary tumors in large degreeafter multiple passages.It is closely related to the tumors of primary patients with great importance in scientific research.The hepatocellular carcinoma PDX models has been used in patients′individualized drug screening,evaluation of drug efficacy,exploration of treatment direction,occurrence and development mechanism of hepatocellular carcinoma,etc.It shows excellent application prospects.This article reviews the methods,applications and tumorigenic factors of hepatocellular carcinoma PDX model.

关 键 词：PDX 肝癌 方法 应用 成瘤因素 研究进展 

分 类 号：R-05[医药卫生] R363-332