大麻二酚在毒品依赖中的干预作用及其机制的研究进展  

Research progress on effect and mechanism of cannabidiol in drug dependence

作　　者：刘柳 杨根梦 沈宝玉 李媛媛 黄俭 刘建兴 张冬先 张瑞林 曾晓锋 LIU Liu;YANG Gen-meng;SHEN Bao-yu;LI Yuan-yuan;HUANG Jian;LIU Jian-xing;ZHANG Dong-xian;ZHANG Rui-lin;ZENG Xiao-feng(School of Forensic Medicine, Kunming Medical University,Kunming 650500,China)

机构地区：[1]昆明医科大学法医学院,云南昆明650500

出　　处：《中国药理学通报》2020年第4期484-487,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金地区基金项目(No 81960340,81860332,81660310);云南省科技厅-昆明医科大学应用基础研究联合专项资金项目[No 2017FE467(-018)];云南省教育厅科学研究基金项目(No 2018Y043);昆明医科大学创新性实验计划项目(201940)。

摘　　要：毒品滥用是当今世界严重的公共卫生和社会问题。由于其具有精神依赖性强、复吸率高和神经毒性大的特点,给家庭和社会带来严重的负面影响。然而针对毒品依赖的有效治疗手段仍然是当今医疗卫生事业的难点。大麻二酚是植物大麻中提取的非毒性成分,已在治疗多种中枢神经系统疾病(如帕金森病、癫痫、阿尔茨海默病等)方面具有潜在价值,受到人们广泛关注。最近研究表明,大麻二酚对吗啡、可卡因、甲基苯丙胺、苯丙胺,酒精等药物诱导的精神依赖具有良好的干预作用,但具体的机制仍然不清楚。该文对大麻二酚在干预毒品依赖中的作用及其相关机制进行综述,旨在进一步研究大麻二酚在治疗毒品依赖中的潜在价值和相关机制,发现新的防治毒品依赖的机制靶点提供重要参考。Drug abuse is a serious public health and social problem in the world today.Due to its strong mental dependence,high relapse rate and high neurotoxicity,it has a serious negative impact on the family and society.However,the effective treatment of drug dependence is still an obstacle in the medical and health care.Cannabidiol is a non-toxic component extracted from plant marijuana,which has potential value in treatment of a variety of nervous system diseases(such as Parkinson′sdisease,epilepsy,Alzheimer′s disease,etc.)and has attracted wide attention.Recent studies have shown that Cannabidiol has a good intervention effect on psycho-dependence induced by methamphetamine,morphine,cocaine,alcohol and other drugs,but the specific mechanism is still unclear.This paper reviews the role of marijuana in the intervention of drug dependence and its related mechanisms,in order to further study the potential value and related mechanisms of marijuana in treatment of drug dependence,aiming to further study the potential value and related mechanisms of cannabidiol in treatment of drug dependence,and to provide important references for discovering new mechanism targets for the prevention and treatment of drug dependence.

关 键 词：大麻二酚 毒品依赖 作用机制 甲基苯丙胺 吗啡 可卡因 

分 类 号：R-05[医药卫生] R282.71