胰高血糖素样肽-1在药物成瘾中的作用及机制  

Role and mechanism of glucagon-like peptide-1 in drug addiction

作　　者：张乐 白洁 ZHANG Le;BAI Jie(Medical School, Kunming University of Science and Technology, Kunming 650500, China)

机构地区：[1]昆明理工大学医学院,云南昆明650500

出　　处：《中国药理学通报》2020年第4期488-491,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81660222,U1202227);云南省高校氧化应激与防御重点实验室(No 2018)。

摘　　要：胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)是一种肠降血糖素,具有调节葡萄糖稳态和食欲的作用,与2型糖尿病和肥胖症的发生发展有关。GLP-1主要通过调节胰岛素的分泌和激活GLP-1受体(GLP-1R)而起作用。最近研究发现GLP-1与可卡因、尼古丁、酒精和苯丙胺类等所致的成瘾行为有关。该文主要对GLP-1在药物成瘾中的作用及机制进行综述。Glucagon-like peptide-1(GLP-1)is an incretin which plays a role in regulating glucose homeostasis and appetite,involved in the occurrence and development of type 2 diabetes and obesity.GLP-1 plays the role through regulating insulin secretion and activating the GLP-1 receptor(GLP-1R).Recent studies have found the association between GLP-1 and addictive behaviors caused by cocaine,nicotine,alcohol and amphetamine.This article reviews the role and mechanism of GLP-1 in drug addiction.

关 键 词：胰高血糖素样肽-1 胰高血糖素样肽-1受体 葡萄糖稳态 食欲 胰岛素 药物成瘾 

分 类 号：R-05[医药卫生] R322.81