莪术醇的结构修饰以及抑制黑色素含量研究  

Structural modification and inhibition of melanin content of curcumol

作　　者：陈亮 陆雪莹[4,5] 黄烈军 蹇军友[2,3] 金军 顾玮[2,3] 苑春茂 郝小江 CHEN Liang;LU Xue-ying;HUANG Lie-jun;JIAN Jun-you;JIN Jun;GU Wei;YUAN Chun-mao;HAO Xiao-jiang(Guizhou University,College of Pharmacy,Guiyang 550025,China;State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical Universitys,Guiyang 550014,China;Key Laboratory of Natural Product Chemistry of Guizhou Academy of Sciences;The State Key Laboratory of Chemistry of Plant Resources in Arid Regions,Chinese Academy of Sciences;The Xinjiang Technical Institute of Physics & Chemistry,Chinese Academy of Sciences,Urumqi 830011,China)

机构地区：[1]贵州大学药学院,贵阳550025 [2]贵州医科大学药用植物功效与利用国家重点实验室 [3]贵州省中国科学院天然产物化学重点实验室,贵阳550014 [4]中国科学院干旱区植物资源化学重点实验室 [5]中国科学院新疆理化研究所,乌鲁木齐830011

出　　处：《天然产物研究与开发》2020年第2期317-322,共6页Natural Product Research and Development

基　　金：中科院西部之光人才培养引进计划(2016-QNXZ-B-5)。

摘　　要：我们利用从莪术油中分离得到的莪术醇考察对B16细胞黑色素的影响,发现其对黑色素有抑制作用。为了进一步对莪术醇的化学结构进行修饰,设计合成了8个莪术醇的衍生物,其中2、3、5a、5b、6为新化合物。经筛选发现两个衍生物5b和6抑制黑色素含量比莪术醇有所增强,但并无较大的显著性差异,经Grphpad prism软件分析,其P值均大于0.05,分别为0.80和0.22。黑色素含量测定结果表明莪术醇环外双键经环氧化、水解及酯化后可提高其抑制黑色素含量。Curcumol isolated from the oil of Oleum curcumae was identified to be inhibited melanin in B16 cells.In order to modification its structure,eight derivatives of curcumol were designed and synthesized,of which 2,3,5a,5b,6 are new compounds.As the result of screening,5b and 6 showed the stronger inhibitory content on melanin than curcumol,but there were no significant differences.According to Grphpad prism software analysis,their P values were all greater than 0.05,which were 0.80 and 0.22,respectively.The result of the melanin content measurement indicated that epoxidation followed by the hydrolyzation and esteration of the exocyclic double bond of curcumol could increase inhibitory content on melanin in B16 cells.

关 键 词：莪术醇 结构修饰 B16细胞 抑制黑色素含量 美白作用 

分 类 号：R914[医药卫生—药物化学]