重复经颅磁刺激治疗帕金森病失眠患者临床分析  

Clinical analysis of repeated transcranial magnetic stimulation in patients with Parkinson's disease

作　　者：陈静[1] 朱红灿[1] CHEN Jing;ZHU Hongcan(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院神经内科,河南郑州450052

出　　处：《中国实用神经疾病杂志》2020年第3期216-219,共4页Chinese Journal of Practical Nervous Diseases

基　　金：2020年度河南省高等学校重点科研项目(编号:20A310025)。

摘　　要：目的探讨帕金森病合并失眠患者应用重复经颅磁刺激技术治疗的效果及预后。方法选取帕金森合并失眠的患者80例,采取数字表抽取法随机分组,对比分析神经内科常规治疗方案(对照组,n=40)与联合重复经颅磁刺激技术治疗(观察组,n=40)的效果及预后。结果观察组总有效率经评定高于对照组(P<0.05)。2组治疗前帕金森病统一评分量表(UPDRS)各维度评分经评测无显著性差异(P>0.05),治疗后各测验分值均有所降低,观察组降低程度显著低于对照组(P<0.05)。2组治疗前睡眠质量量表(PSQI)各维度评分经评测无显著性差异(P>0.05),治疗后各维度评测分值均不同程度降低,观察组降低程度显著低于对照组(P<0.05)。2组治疗前神经递质多巴胺(DA)、5-羟色胺(5-HT)无显著性差异(P>0.05),治疗后各测验值均有所升高,观察组更为显著(P<0.05)。2组间不良反应比较无明显差异(P>0.05)。结论重复经颅磁刺激可提高帕金森合并失眠患者总有效率,改善临床症状,提高睡眠质量,且具有较高安全性。Objective To investigate the therapeutic effect and prognosis of repetitive transcranial magnetic stimulation(TMS)in patients with Parkinson’s disease combined with insomnia.Methods 80 cases suffering from Parkinson’s disease and merger of insomnia patients shall be selected and were analyzed,taking digital table extraction method randomized,apply neurology conventional treatment(control group,n=40)and application of combined repetitive transcranial magnetic stimulation technology treatment(observation group,n=40)contrast effect and prognosis.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).Before treatment,there was no difference in all dimensions of Parkinson’s disease rating scale(UPDRS)between the two groups(P>0.05).After the treatment,the scores of each test were all reduced,compared with the control group,the observation group had a more obvious reduction.Before the treatment,there was no difference in the scores of all dimensions of the sleep quality scale(PSQI)between the two groups(P>0.05).After the treatment,the scores of each test were all reduced,compared with the control group,the observation group had a more obvious reduction.Before the treatment,there was no difference between the two groups in the neurotransmitters dopamine(DA)and 5-HT(P>0.05).After the treatment,all the test values increased,which was more significant in the observation group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion In patients with Parkinson’s disease and insomnia,paying attention to the development of repeated transcranial magnetic stimulation(TMS)can improve the efficiency,improve clinical symptoms,enhance the quality of sleep,and have a higher safety.

关 键 词：帕金森病 失眠 重复经颅磁刺激技术 睡眠质量 神经递质水平 

分 类 号：R742.5[医药卫生—神经病学与精神病学]