血清CEA、CYFRA21-1、VEGF、STK1及SF联合检测在非小细胞肺癌患者诊断中的价值分析  

The Clinical Value of Serum CEA,CYFRA21-1,VEGF,STK1 and SF in the Diagnosis of Non-small Cell Lung Cancer

作　　者：范伟[1] 孙振宇[1] 孟祥宽[1] 任宇峰[1] FAN Wei;SUN Zhenyu;MENG Xiangkaun;REN Yufeng(Cardiothoracic Surgery, Beijing Renhe Hospital, Beijing 102600, China)

机构地区：[1]北京市仁和医院心胸外科,北京102600

出　　处：《标记免疫分析与临床》2020年第3期480-483,507,共5页Labeled Immunoassays and Clinical Medicine

基　　金：北京市科委“首都临床特色应用研究”专项课题(编号:Z171100001017102)。

摘　　要：目的研究非小细胞肺癌(NSCLC)患者血清CEA、CYFRA21-1、VEGF、STK1及SF水平的诊断价值。方法选取2018年7月至2019年6月在我院收治的85例NSCLC患者为研究组,85例肺部良性疾病患者作为对照组以及85例健康体检者作为健康组,对比分析3组人群的CEA、CYFRA21-1、VEGF、STK1及SF水平,以及采用Logistic多因素回归分析与NSCLC疾病的关系,并联合检测CEA、CYFRA21-1、VEGF、STK1及SF水平判断NSCLC的诊断效能。结果研究组和对照组的血清CEA、CYFRA21-1、VEGF、STK1以及SF水平均显著高于健康组(P<0.05),且研究组的血清CEA、CYFRA21-1、VEGF、STK1以及SF水平均显著高于对照组(P<0.05)。Logistic回归分析结果显示血清CEA、CYFRA21-1、VEGF、STK1以及SF水平均是NSCLC疾病的独立危险因素。除灵敏度稍低于SF指标检测外,联合检测的灵敏度、特异性、约登指数及ROC曲线下面积均高于三者的单独检测,具有较好的诊断价值。结论采用CEA、CYFRA21-1、VEGF、STK1及SF水平的联合检测对NSCLC疾病具有较高诊断效能,能够比较方便、快捷、实时地发现高危人群,具有很好的临床参考价值。Objective To study the diagnostic value of serum CEA,CYFRA21-1,VEGF,STK1 and SF levels in patients with non-small cell lung cancer(NSCLC).Methods 85 NSCLC patients admitted to our hospital from July,2018 to June,2019 were selected as the study group,while 85 patients with pulmonary benign diseases as the control group and 85 healthy people as the health group.The CEA,CYFRA21-1,VEGF,STK1 and SF levels of the three groups were compared,and the relationships between these three groups with NSCLC disease were analyzed by logistic multiple factor regression analysis.Also,the combined detection of CEA,CYFRA21-1,VEGF,STK1 and SF levels to determine the diagnostic efficacy of NSCLC was evaluated.Results The levels of CEA,CYFRA21-1,VEGF,STK1 and SF in the study group and the control group were significantly higher than those in the healthy group(P<0.05),and the levels of CEA,CYFRA21-1,VEGF,STK1 and SF in the study group were significantly higher than those in the control group(P<0.05).Logistic regression analysis showed that serum CEA,CYFRA21-1,VEGF,STK1 and SF levels were independent risk factors of NSCLC.In addition to the sensitivity which was slightly lower than SF index detection,the sensitivity,specificity,Jordan index and area under ROC curve of the combined detection were all higher than those of three individual detections,suggesting a better diagnostic value.Conclusion Combining CEA,CYFRA21-1,VEGF,STK1 and SF levels to diagnose NSCLC disease has a high detection efficiency.This method is convenient,fast and can find high-risk groups in real-time,which has a good clinical reference value.

关 键 词：非小细胞肺癌 CEA CYFRA21-1 VEGF STK1 SF 联合检测 

分 类 号：R734.2[医药卫生—肿瘤]