复方盐酸阿替卡因在中老年人活髓牙牙体预备中麻醉效果的研究  

A Study on the Anesthetic Effect of Compound Articaine Hydrochloride in the Preparation of Vital Pulp Teeth in Middle and Old-aged Population

作　　者：任桂芳[1] REN Guifang(Department of Stomatology,Hepingli Hospital,Beijing 100013,China)

机构地区：[1]北京市和平里医院口腔科,北京100013

出　　处：《标记免疫分析与临床》2020年第3期493-496,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：目的评估国产复方盐酸阿替卡因在中老年人活髓牙牙体预备中麻醉效果。方法选择需要做基牙是活髓牙的全瓷冠修复的患者141例,活髓基牙共153颗,按电脑随机数随机分为3组。观察组为国产复方盐酸阿替卡因(49颗),对照1组为法国碧兰麻(51颗),对照2组为盐酸利多卡因(53颗),分别进行局部浸润麻醉。根据患者表情及医生评估,对其镇痛效果、麻醉的起效时间和维持时间及不良反应发生率进行观察分析。结果观察组的镇痛有效率(显效+有效)为95.91%,起效时间均为2.84 min,维持时间为2.8±0.5 h,对照1组的镇痛有效率(显效+有效)为96.08%,起效时间均为2.80 min,维持时间为2.8±0.6 h,对照2组的镇痛有效率(显效+有效)为79.25%,起效时间均为3.38 min,维持时间为1.5±0.4 h。观察组和对照1组镇痛效果与起效时间及维持时间,经统计学分析差异无统计学意义。观察组和对照2组、对照1组和对照2组镇痛效果与起效时间及维持时间,经统计学分析差异有统计学意义。三组患者均无药物引起的局部疼痛、水肿、头晕、恶心呕吐和过敏等不良反应。结论国产复方盐酸阿替卡因麻醉效果和进口的碧兰麻效果相似。在中老年人全瓷冠牙体预备时是一种起效快、麻醉力强、不良反应小的安全可靠、值得推广使用的口腔局部麻醉药。Objective To evaluate the anesthetic effect of Compound Articaine hydrochloride injection in the preparation of vital pulp teeth in middle and old-aged population.Methods According to the inclusion criteria and exclusion criteria of clinical trials,141 patients with vital pulp teeth were selected for crown and bridge restoration.153 vital pulp abutments were randomly divided into three groups.The observation group consisted of 49 domestic compound articaine hydrochloride injection,while the control group 1 consisted of 51 French articaine hydrochloride and epinephrine tartrate injection and the control group 2 consisted of 53 lidocaine hydrochloride.According to the patient′s expression and doctor′s evaluation,the analgesic effect,the onset time and maintenance duration of anesthesia and the incidence of adverse reactions were observed and analyzed.Results The effective rate(significant+effective)was 95.91%in the observation group,with 2.84 minutes for the onset time,2.8±0.5h for the maintenance duration,while 96.08%in the control group 1,with 2.80 minutes for the onset time,2.8±0.6h for the maintenance duration,and 79.25%in the control group 2,with 3.38 minutes for the onset time and 1.5±0.4h for the maintenance duration.There was no significant difference in analgesic effect,onset time and maintenance duration between the observation group and the control group 1.There were significant differences in analgesic effect,onset time and maintenance duration between the observation group and control group 2,also between control group 1 and control group 2.There were no adverse reactions such as local pain,edema,dizziness,nausea,vomiting and allergy caused by drugs in all three groups.Conclusion The anesthesia effect of domestic compound articaine hydrochloride injection is similar to that of French articaine hydrochloride and epinephrine tartrate injection.In the preparation of all ceramic crowns for middle and old-aged population,it is a safe and reliable local anesthetic with quick effect,strong anesthesia a

关 键 词：复方盐酸阿替卡因 局部麻醉 全瓷冠 牙体预备 

分 类 号：R787[医药卫生—口腔医学]