T1期乳腺癌前哨淋巴结转移的影响因素  

Influencing factors of sentinel lymph node metastasis in stage T1 breast cancer

作　　者：傅成斌[1] 林舜国[1] 许春森[1] 韩晖[1] FU Cheng-bin;LIN Shun-guo;XU Chun-sen;HAN Hui(Department of Breast Surgery,Fujian Medical University Union Hospital,Fuzhou350001,China)

机构地区：[1]福建医科大学附属协和医院乳腺外科,福建福州350001

出　　处：《中国当代医药》2020年第8期12-15,共4页China Modern Medicine

摘　　要：目的 探讨T1期乳腺癌前哨淋巴结转移的影响因素.方法 回顾性分析2018年1~12月福建医科大学附属协和医院乳腺外科收治的58例T1期乳腺癌患者的病史资料,所有患者均接受前哨淋巴结活检,针对可能的影响因素包括:年龄、肿瘤大小、肿瘤位置、术前影像学评估、分子分型、组织学分级、Ki67和脉管瘤栓八个因素进行单因素及多因素分析.结果 58例患者中,前哨淋巴结转移者1 1例,阳性率为18.97%.单因素分析显示,不同组织学分级、Ki67和脉管瘤栓情况下的前哨淋巴结阳性率比较,差异有统计学意义(P<0.05).多因素分析显示,脉管瘤栓是T1期乳腺癌前哨淋巴结转移的独立危险因素(β=1.792,OR=5.999,95%CI:1.151~31.269,P=0.033).结论 脉管瘤栓可以预测T1期乳腺癌前哨淋巴结转移.Objective To explore the influencing factors of sentinel lymph node metastasis in stage T1 breast cancer.Methods The clinical data of 58 patients with stage T1 breast cancer treated in our hospital from January to December 2018 were retrospectively analyzed.All patients underwent sentinel lymph node biopsy.Univariate and multivariate analysis was made on the possible influencing factors including age,tumor size,tumor location,preoperative imaging evaluation,molecular typing,histological grade,Ki67 and lymphovascular invasion.Results Among 58 patients,11 cases had sentinel lymph node metastasis,the positive rate was 18.97%.Univariate analysis showed that there were statistically significant differences in the positive rates of sentinel lymph nodes under different histological grades,Ki67,and lymphovascular invasion(P<0.05).Multivariate analysis showed that lymphovascular invasion was an independent risk factor for sentinel lymph node metastasis in T1 stage breast cancer(β=1.792,OR=5.999,95%CI:1.151-31.269,P=0.033).Conclusion Lymphovascular invasion can predict sentinel lymph node metastasis in stage T1 breast cancer.

关 键 词：T1期乳腺癌 前哨淋巴结活检 多因素分析 脉管瘤栓 

分 类 号：R737.9[医药卫生—肿瘤]