益生菌含片联合基础牙周治疗对慢性牙周炎伴口臭患者口腔微生态的影响  

Effect of Probiotics Buccal Tablets combined with basic periodontal treatment on oral microecology of patients with chronic periodontitis accompanied by bad breath

作　　者：李雁[1] 吴海燕[1] 王玉娥 李惠山[1] LI Yan;WU Hai-yan;WANG Yu-e;LI Hui-shan(Department of Stomatology,Dalian Friendship Hospital,Liaoning Province,Dalian 116001,China)

机构地区：[1]大连市友谊医院口腔科,辽宁大连116001

出　　处：《中国当代医药》2020年第8期121-123,共3页China Modern Medicine

摘　　要：目的 探讨益生菌含片联合基础牙周治疗对慢性牙周炎伴口臭患者口腔微生态的影响.方法 选取我院2016年2月~2019年2月收治的74例慢性牙周炎伴口臭患者作为研究对象,按照随机数字表法分为观察组(37例)和对照组(37例),对照组采用基础牙周治疗,观察组采用益生菌含片联合牙周基础治疗,比较两组的唾液白介素-6、白介素-10、口腔致病菌群、基质金属蛋白酶-9的水平以及治疗效果.结果 观察组的唾液白介素-6和基质金属蛋白酶-9低于对照组,差异有统计学意义(P<0.05).观察组白介素-10水平高于对照组,差异有统计学意义(P<0.05).观察组口腔致病菌群各项均低于对照组,差异有统计学意义(P<0.05).观察组临床治疗总有效率高于对照组,差异有统计学意义(P<0.05).结论 在慢性牙周炎伴口臭患者中采用益生菌含片联合牙周基础治疗,可以有效降低白介素-6和基质金属蛋白质酶-9,提升白介素-10,改善口腔致病菌群,有较好的临床治疗效果,临床具有一定的运用价值,应该广泛运用于临床.Objective To explore the effect of Probiotics Buccal Tablets combined with basic periodontal treatment on oral microecology of patients with chronic periodontitis accompanied by bad breath.Methods A total of 74 patients with chronic periodontitis accompanied by bad breath treated in our hospital from February 2016 to February 2019 were selected as the research subjects.They were divided into the observation group(n=37)and the control group(n=37)according to the random number table method.Basic periodontal treatment was used in the control group.In the observation group,Probiotics Buccal Tablets combined with basic periodontal treatment was adopted.The salivary interleukin-6,interleukin-10,oral pathogenic flora,matrix metalloproteinase-9 levels and treatment effect were compared in the two groups.Results The levels of salivary interleukin-6 and matrix metalloproteinase-9 in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The level of interleukin-10 in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The oral pathogenic bacteria in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total effectiveness rate of clinical treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion In patients with chronic periodontitis accompanied by bad breath,the use of Probiotics Buccal Tablets combined with periodontal basic treatment can effectively reduce the levels of interleukin-6 and matrix metalloproteinase-9,increase interleukin-10 level,and improve oral pathogenic flora.It can obtain a favorable clinical treatment effect,with certain application value,and should be widely used in the clinic.

关 键 词：益生菌含片 基础牙周治疗 慢性牙周炎 口臭 口腔微生态 

分 类 号：R781.3[医药卫生—口腔医学]