血清鳞状细胞癌抗原、糖链抗原125、糖链抗原199水平表达对宫颈小细胞癌患者预后的评估价值  

Evaluation value of serum squamous cell carcinoma antigen,carbohydrate antigen 125 and carbohydrate antigen 199 expression for prognosis of patients with small cell carcinoma of cervix

作　　者：王琪 王楠[2] 刘丹 WANG Qi;WANG Nan;LIU Dan(Department of Clinical Laboratory,Dalian Maternal and Child Health Hospital,Liaoning Province,Dalian 116000,China;Department of Clinical Laboratory,the First Affiliated Hospital of Dalian Medical University,Liaoning Province,Dalian 116000,China)

机构地区：[1]大连市妇幼保健院检验科,辽宁大连116000 [2]大连医科大学附属第一医院检验科,辽宁大连116000

出　　处：《中国当代医药》2020年第8期169-171,F0004,共4页China Modern Medicine

摘　　要：目的 探究血清鳞状细胞癌抗原(SCC)、糖链抗原125(CA125)、糖链抗原199(CA199)水平表达对宫颈小细胞癌(SCCC)患者预后的评估价值.方法 选取2018年1月~2019年1月于大连市妇幼保健院确诊为SCCC的58例患者作为观察组,另选取58例同期体检健康女性作为对照组.检测对照组及观察组治疗前后的SCC、CA125、CA199水平.按照预后情况不同将SCCC患者分为治疗有效组和治疗无效组,比较两组的SCC、CA125、CA199水平.结果 观察组治疗前后的SCC、CA125、CA199水平均高于对照组,差异有统计学意义(P<0.05).出院后第4个月,58例SCCC患者中,36例治疗有效,22例治疗无效;治疗无效组的SCC、CA125、CA199水平均高于治疗有效组,差异有统计学意义(P<0.05).受试者工作特征(ROC)曲线分析显示,SCC、CA125、CA199三者联合检测的曲线下面积(AUC)大于SCC、CA125、CA199单独检测,差异有统计学意义(P<0.05).结论 血清SCC、CA125、CA199对SCCC有较高的诊断价值,可作为患者预后评估的指标.Objective To explore evaluation value of expression of serum squamous cell carcinoma antigen(SCC),carbohydrate antigen 125(CA125)and carbohydrate antigen 199(CA199)for prognosis of patients with small cell carcinoma of cervix(SCCC).Methods A total of 58 patients diagnosed with SCCC in Dalian Maternal and Child Health Hospital from January 2018 to January 2019 were enrolled as the observation group,and 58 healthy women who underwent physical examination during the same period were enrolled as the control group.The levels of SCC,CA125 and CA199 in the control group and in the observation group before and after treatment were detected.According to different prognosis,the SCCC patients were divided into effective treatment group and ineffective treatment group,and the levels of SCC,CA125 and CA199 were compared between the two groups.Results The levels of SCC,CA125 and CA199 in observation group before and after treatment were higher than those in control group,and the differences were statistically significant(P<0.05).At the fourth month after discharge,of the 58 SCCC patients,there were 36 cases with effective treatment,and 22 cases with ineffective treatment.The levels of SCC,CA125 and CA199 in the ineffective treatment group were higher than those in the effective treatment group,and the differences were statistically significant(P<0.05).The receiver operating characteristic(ROC)curve analysis showed that the area under the curve(AUC)of the combined detection of SCC,CA125,and CA199 was larger than that of SCC,CA125,and CA199 alone,and the difference was statistically significant(P<0.05).Conclusion Serum SCC,CA125,CA199 are of relatively higher diagnostic value for SCCC,which can be applied as indexes for prognosis evaluation.

关 键 词：宫颈小细胞癌 鳞状细胞癌抗原 糖链抗原125 糖链抗原199 

分 类 号：R737.33[医药卫生—肿瘤]