STZ因素与高脂饮食对制备妊娠期糖尿病大鼠模型的影响研究  

Effect of STZ Factors and High-fat Diet on the Rat Model of Gestational Diabetes

作　　者：修贤杰 张萍[1] 郑小鹏 朱思源 陈光 Xiu Xianjie;Zhang Ping;Zheng Xiaopeng;Zhu Siyuan;Chen Guang(Department of Clinical Medicine,Jiamusi University,Jiamusi 154000;The First Affiliated Hospital of Jiamusi University,Jiamusi 154000;Taizhou University Medical College,Taizhou 318000,China)

机构地区：[1]佳木斯大学医学部临床医学院,黑龙江佳木斯154000 [2]佳木斯大学附属第一医院,黑龙江佳木斯154000 [3]台州学院医学院,浙江台州318000

出　　处：《广东化工》2020年第5期105-106,共2页Guangdong Chemical Industry

基　　金：黑龙江省大学生创新项目,编号:201710222028;佳木斯大学交叉学科项目,编号:12J201503。

摘　　要：妊娠期糖尿病(gestationaldiabetesmellitus,GDM)是指孕妇在怀孕前无高血糖表现,随着妊娠周数的增长和妊娠过程的发展,出现高血糖表现。目前随着生活水平的逐渐提高,GDM的发病率呈逐年增长趋势,严重危害孕妇和胎儿的健康,但GDM的致病机制仍未完全阐明,可以肯定的是胰岛素抵抗在GDM发病中起关键作用。目前GDM动物模型的建立多是结合糖尿病模型建立方法来进行建立的,建立合适的GDM模型是研究GDM发病机理的基础。如今建立GDM模型最常用的方法是注射STZ进行造模实验。本文从STZ剂量,高脂饮食,造模方法,成模标准几个方面上进行概述。Gestational diabetes mellitus (GDM) refers to the absence of hyperglycemia in pregnant women before pregnancy. With the increase of gestational weeks and the development of pregnancy, hyperglycemia appears. At present, with the gradual improvement of living standards, the incidence of GDM is increasing year by year, which seriously harms the health of pregnant women and fetuses, but the pathogenic mechanism of GDM has not been fully elucidated. It is certain that insulin resistance plays a key role in the pathogenesis of GDM. At present, the establishment of GDM animal models is mostly combined with the establishment of a diabetes model. The establishment of a suitable GDM model is the basis for studying the pathogenesis of GDM. Nowadays, the most commonly used method for establishing GDM models is injection of STZ for modeling experiments. This article summarizes the aspects of STZ dosage, high-fat diet, modeling methods, and modeling standards.

关 键 词：妊娠期糖尿病(GDM) 高脂饮食 链脲佐菌素(STZ) 动物模型 

分 类 号：TQ[化学工程]