小分子蛋白降解剂SNIPERs的研究进展  

Development of SNIPERs Induced Protein Degradation

作　　者：吉钰 孙海鹰 Ji Yu;Sun Haiying(Jiangsu Key Laboratory of Drug Design and Optimization,Department of Medicinal Chemistry,School of Pharmacy,China Pharmaceutical University,Nanjing 2111981,China)

机构地区：[1]江苏省新药分子设计与成药性优化重点实验室,中国药科大学药学院药物化学系,江苏南京211198

出　　处：《广东化工》2020年第6期95-96,共2页Guangdong Chemical Industry

基　　金：国家自然科学基金(81673288)。

摘　　要：SNIPERs(specific and nongenetic IAP-dependent protein erasers)是一类由凋亡抑制蛋白IAPs(inhibitor of apoptosis proteins)的配体与靶蛋白的配体嵌合而成的小分子蛋白降解剂。这类分子可以利用IAPs的E3泛素连接酶的性质促使靶蛋白泛素化,从而使靶蛋白被蛋白酶体降解。本文对近年来SNIPERs的研究进展进行了总结,并对将来的工作进行了展望。Specific and non-genetic inhibitor of apoptosis protein(IAP)-dependent protein erasers(SNIPERs) is a class of chimeric molecules for protein degradation, composed of IAPs ligands and target protein ligands. SNIPERs could recruit IAPs as E3 ubiquitin ligases to make target protein ubiquitinated and then degraded by proteasome. In this review we summarize the development of SNIPERs in recent years, and provide perspection of SNIPERs in the future.

关 键 词：IAPS SNIPER 泛素蛋白酶体系统 抗肿瘤药 

分 类 号：TQ[化学工程]