SNIPERs(specific and nongenetic IAP-dependent protein erasers)是一类由凋亡抑制蛋白IAPs(inhibitor of apoptosis proteins)的配体与靶蛋白的配体嵌合而成的小分子蛋白降解剂。这类分子可以利用IAPs的E3泛素连接酶的性质促使靶蛋...
This work was supported by the National Natural Science Foundation of China(NSFC 21627812&21676156).
Mutations,serving as the raw materials of evolution,have been extensively utilized to increase the chances of engineering molecules or microbes with tailor-made functions.Global and targeted mutagenesis are two main m...