术前肠内营养支持治疗在口腔鳞癌患者加速康复中的应用  

Application of preoperative enteral nutrition support in patients with oral squamous cell carcinomas in the enhanced recovery after surgery

作　　者：王延 蒋通辉 庄海[1] 张继生[1] 卜寿山[1] WANG Yan;JIANG Tong-hui;ZHUANG Hai;ZHANG Ji-sheng;BU Shou-shan(Department of Stomatology,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China)

机构地区：[1]南京医科大学第一附属医院口腔科,江苏南京210029

出　　处：《中国口腔颌面外科杂志》2020年第2期122-126,共5页China Journal of Oral and Maxillofacial Surgery

基　　金：国家自然科学基金(81670967)。

摘　　要：目的:评估口腔癌患者术前肠内营养支持的效果。方法:将56例确诊口腔鳞癌的患者分为试验组(37例)和对照组(19例),试验组在常规饮食的基础上术前连续口服营养制剂7 d以上,对照组术前常规饮食。记录患者围术期体重指数、血清白蛋白、血清前白蛋白、血清离子浓度变化以及术后营养相关不良反应、术后并发症、术后首次排气时间、术后住院天数、总住院费用。采用SPSS 17.0软件包进行数据录入与分析。结果:试验组患者术后第7天血清白蛋白、术后第3天和第7天血清前白蛋白量、出院时体重指数显著高于对照组;试验组患者术后恶心、呕吐、腹泻、便秘发生率显著低于对照组;试验组患者相比于对照组患者术后首次排气时间、术后住院天数显著缩短,总住院费用显著降低(P<0.05)。结论:给予口腔鳞癌手术患者术前肠内营养支持是一种安全有效的治疗方式,可改善患者术后营养状况,有效降低术后营养相关不良反应发生率,缩短术后住院时间,降低住院费用。PURPOSE:To evaluate the effect of preoperative enteral nutrition support for patients with oral squamous cell carcinomas.METHODS:Fifty-six patients with oral squamous cell carcinoma were divided into experimental group(n=37)and control group(n=19).On the basis of routine diet,patients in the experimental group received oral nutritional preparations for more than 7 days before operation,while patients in the control group received routine diet before operation.The changes of body mass index,serum albumin,serum prealbumin,serum ion concentration,nutrition-related adverse reactions,complications,first exhaust time,hospital stay and total hospitalization expenses were recorded.SPSS 17.0 software package was used for data input and analysis.RESULTS:The serum albumin,at 7 days prealbumin and body mass index,at 3 days and 7 days after operation in the experimental group were significantly higher than those in the control group;the incidence of nausea,vomiting,diarrhea and constipation in the experimental group was significantly lower than that in the control group;the experimental group was significantly lower than that in the control group at the first time of exhaust after operation;the duration of hospitalization and the total cost of hospitalization in the experimental group were significantly shortened(P<0.05).CONCLUSIONS:Preoperative enteral nutrition support is a safe and effective treatment for oral squamous cell carcinoma patients.It can improve the nutritional status of patients after operation,effectively reduce the incidence of nutrition-related adverse reactions after operation,shorten the length of hospital stay after operation and reduce the cost of hospitalization.

关 键 词：肠内营养 口腔癌 预适应 术后加速康复 

分 类 号：R739.8[医药卫生—肿瘤]