对比分析卡马西平联合丙戊酸钠、单用卡马西平治疗癫痫的临床疗效及其不良反应  

Comparative analysis of clinical efficacy and adverse reactions of carbamazepine combined with sodium valproate and carbamazepine alone in the treatment of patients with epilepsy

作　　者：孔婵娟 聂浩鸿[1] Kong Chanjuan;Nie Haohong(Department of Pharmacy,Guizhou Provincial People's Hospital,Guiyang 550002,China)

机构地区：[1]贵州省人民医院药剂科,贵阳550002

出　　处：《北方药学》2020年第2期144-145,共2页Journal of North Pharmacy

摘　　要：目的:分析卡马西平联合丙戊酸钠、单用卡马西平治疗癫痫的疗效及不良反应。方法:选择我院2018年1—12月收治的癫痫患者62例作为研究对象,按照治疗方法的不同分为研究组(卡马西平联合丙戊酸钠治疗)和对照组(卡马西平治疗),比较两组治疗前后的癫痫发作次数和每次发作时间、MoCA评分、HAMD评分、HAMA评分。结果:研究组临床指标在治疗后均显著优于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:卡马西平联合丙戊酸钠能有效改善癫痫发作次数和发作时间,提高认知水平,有利于情绪功能改善,疗效突出,安全性高,值得推广。Objective:To analyze the efficacy and adverse reactions of mazepine combined with sodium valproate and carbamazepine alone in the treatment of patients with epilepsy.Methods:A total of 62 patients with epilepsy admitted to our hospital from January 20 to December 2018 were enrolled.The patients were divided into study group(carbamazepine combined with sodium valproate)and control group according to different treatment methods.(Carbamazepine treatment),the number of seizures and the time of each episode,MoCA score,HAMD score,and HAMA score before and after treatment were compared between the two groups.Reults:The clinical indicators of the study group were significantly better than the control group after treatment(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Carbamazepine combined with sodium valproate can effectively improve the number and time of seizures in patients with epilepsy,improve the cognitive level of patients,improve the emotional function of patients,with outstanding curative effect,high safety and worth promoting.

关 键 词：卡马西平 丙戊酸钠 癫痫 疗效 不良反应 

分 类 号：R742.1[医药卫生—神经病学与精神病学]