经尿道钬激光膀胱肿瘤切除术与经尿道膀胱肿瘤电切术治疗浅表层膀胱癌的效果对比  

Comparison between Transurethral Holmium Laser Resection of Bladder Tumor and Transurethral Resection of Bladder Tumor on Superficial Bladder Cancer

作　　者：郑会忠 杨文博[2] 王守林 郭国营[2] ZHENG Huizhong;YANG Wenbo;WANG Shoulin(Henan Rongjun hospital,Xinxiang,453002)

机构地区：[1]河南省荣军医院,453002 [2]河南省新乡市中心医院,453002

出　　处：《实用癌症杂志》2020年第4期628-631,共4页The Practical Journal of Cancer

基　　金：河南省医学科技攻关计划项目(编号:2018020938)。

摘　　要：目的探究经尿道钬激光膀胱肿瘤切除术与经尿道膀胱肿瘤电切术治疗浅表层膀胱癌的效果。方法选取82例表浅层膀胱癌患者,并将患者随机分成2组,每组41例。对照组采用经尿道膀胱肿瘤电切术进行治疗,观察组采用经尿道钬激光膀胱肿瘤切除术进行治疗。观察比较2组患者的手术相关指标,血清指标,炎症因子水平,并发症发生情况。结果观察组患者的膀胱冲洗时间、术中出血量、住院时间、尿管留置时间明显比对照组少,差异具有统计学意义(P<0.05)。观察组患者治疗后的纤维蛋白原(Fib)明显比对照组高(P<0.05),肿瘤特异性生长因子(TSGF)、肝细胞生长因子(HGF)水平明显比对照组低(P<0.05)。观察组患者治疗后的肿瘤坏死因子(TNF-α)、白细胞介素10(IL-10)、白细胞介素8(IL-8)、白细胞介素6(IL-6)水平明显比对照组低,2组数据存在明显差异(P<0.05)。观察组患者的并发症发生率为4.88%,对照组患者的并发症发生率为21.95%,2组数据存在明显差异(P<0.05)。结论经尿道钬激光膀胱肿瘤切除术治疗表浅层膀胱癌的效果优于经尿道膀胱肿瘤电切术。经尿道钬激光膀胱肿瘤切除术能够有效改善手术指标,炎症因子水平和血清指标水平,减少并发症的发生。Objective To explore the effects of transurethral holmium laser resection of bladder tumor(HOLBT)and transurethral resection of bladder tumor(TURB)on superficial bladder cancer.Methods 82 patients with superficial bladder cancer were selected,and the patients were randomly divided into 2 groups,with 41 cases in each group.One group was treated by TURB as control group,the other group was treated with transurethral HOLBT as observation group.The surgical indicators,serum indicators,inflammatory cytokines and complications of the 2 groups were observed and compared.Results Bladder irrigation time,intraoperative blood loss,length of stay and indwelling time in the observation group were significantly less than those of the control group(P<0.05).The serum indexes of the observation group were significantly higher than those of the control group,and tumor specific growth factor(TSGF)and hepatocyte growth factor(HGF)in the observation group were significantly lower than those of the control group(P<0.05).The levels of inflammatory cytokines including tumor necrosis factor(tnf-alpha),interleukin 10(il-10),interleukin 8(il-8)and interleukin 6(il-6)in the observation group were significantly lower than those of the control group(P<0.05).The complication rate in the observation group was 4.88%,and that of the control group was 21.95%,There were significant differences between the 2 groups,which were statistically significant(P<0.05).Conclusion HOLBT is better than TURB in treating superficial bladder cancer,which can effectively improve the level of surgical indicators,inflammatory cytokines and serum indicators,reduce the occurrence of complications,and promote the treatment of patients.

关 键 词：经尿道钬激光膀胱肿瘤切除术 经尿道膀胱肿瘤电切术 浅表层膀胱癌 

分 类 号：R737.14[医药卫生—肿瘤]