氟比洛芬酯在宫颈癌手术患者围术期镇痛效果观察及对免疫系统的影响  

Perioperative Analgesic Effect of Flurbiprofen Axetil in Patients Undergoing Cervical Cancer Surgery and Its Effect on Immune System

作　　者：王根生[1] 卢锡华[1] 杨清存[1] 李延坤 WANG Gensheng;LU Xihua;YANG Qingcun(Henan Cancer Hospital,Zhengzhou,450008)

机构地区：[1]河南省肿瘤医院,450008

出　　处：《实用癌症杂志》2020年第4期651-655,共5页The Practical Journal of Cancer

基　　金：2014年度河南省医学科技攻关计划项目(编号:20140459)。

摘　　要：目的探讨氟比洛芬酯在宫颈癌手术患者围术期镇痛效果及对免疫系统的影响,为治疗宫颈癌提供理论依据。方法选取100例择期行宫颈癌根除术患者为研究对象,随机分为2组,观察组50例患者,采用氟比洛芬酯镇痛,对照组50例患者,对应的注射等量生理盐水。观察记录患者的一般病理特征。视觉模拟评分和舒适评分,记录患者体温、恶性呕吐及患者失血量、白细胞水平和肛门排气时间、CD3^+、CD4^+、CD8+、CD4^+/CD8+和CD25^+等指标。结果观察组患者术后12 h、24 h、36 h和48 h视觉模拟评分均低于对照组患者、舒适评分均高于对照组患者,差异有统计学意义(P<0.05);观察组患者肛门恢复排气时间短于对照组患者,恶心呕吐发生率明显低于对照组患者,观察组患者手术之后白细胞水平低于对照组患者,观察组患者手术之后24 h体温升高幅度小于对照组患者,差异有统计学意义(P<0.05);2组患者各项T淋巴细胞均在术后24 h达到最低,观察组患者术后24 h CD8+和CD4^+/CD8+高于对照组,差异有统计学意义(P<0.05),观察组患者术后48 h CD4^+和CD4^+/CD8+高于对照组,差异有统计学意义(P<0.05);观察组患者术后24 h和48 h CD25^+水平均高于对照组患者,差异有统计学意义(P<0.05)。结论氟比洛芬酯对宫颈癌手术患者围术期具有较好的镇痛效果,对患者免疫功能有一定的保护作用,临床效果好。Objective To investigate the analgesic effect of flurbiprofen ester in patients with cervical cancer surgery and its effect on the immune system,and to provide theoretical basis for the treatment of cervical cancer.Methods A total of 100 patients undergoing elective cervical cancer eradication were randomly divided into 2 groups,50 patients in the observation group were treated with flurbiprofen analgesia,and 50 patients in the control group were injected with the same amount of normal saline.Observe and record the general pathological characteristics of patients.Comfort and visual analogue scale score,record a patient's temperature,blood loss in patients with malignant and vomiting,and white blood cell levels of flatus,CD3^+,CD4^+,CD8^+,CD4^+/CD8^+ and CD25^+ and other indicators.Results The visual analogue scores of patients in the observation group at 12 h,24 h,36 h,and 48 h after surgery were lower than those in the control group,and the comfort scores were higher than those in the control group,and the difference was statistically significant(P<0.05).Shorter than the patients in the control group,the incidence of nausea and vomiting was significantly lower than those in the control group.The levels of white blood cells after surgery in the observation group were lower than those of the control group.(P<0.05);T lymphocytes of the 2 groups reached the lowest at 24 hours after operation.The patients in the observation group had higher CD8^+and CD4^+/CD8^+than those of the control group at 24 hours after operation.The difference was statistically significant(P<0.05).The observation group CD4^+and CD4^+/CD8^+were higher in patients at 48h after operation than those in the control group,and the difference was statistically significant(P<0.05).Patients in the observation group had higher CD25^+levels at 24 h and 48 h after operation than those of the control group,and the difference was statistically significant(P<0.05).Conclusion Flurbiprofen ester has a good analgesic effect on patients with cervical cancer surge

关 键 词：氟比洛芬酯 宫颈癌 镇痛效果 免疫系统 

分 类 号：R737.33[医药卫生—肿瘤]