丙泊酚靶控输注在老年消化道肿瘤术中应用的价值  

Value of Target-controlled Infusion of Propofol in Elderly Patients with DigestiveTract Tumors

作　　者：任斐[1] 徐小矛 刘涛[1] REN Fei;XU Xiaomao;LIU Tao(Yan’an University Affiliated Hospital,Yan’an,716000)

机构地区：[1]延安大学附属医院,716000

出　　处：《实用癌症杂志》2020年第4期680-682,共3页The Practical Journal of Cancer

基　　金：陕西省2016年科学技术研究发展计划项目(编号:2016SF-075)。

摘　　要：目的探究老年消化道肿瘤术中靶控输注丙泊酚的临床效果和安全性。方法选取84例老年消化道肿瘤患者作为研究对象,按照随机数字表法分为2组,对照组患者42例采用静脉持续输注丙泊酚麻醉,观察组患者则采用靶控输注丙泊酚麻醉。使用改良警觉/镇静评分(OAA/S)量表对2组患者麻醉效果进行评估,记录术后患者睁眼时间、拔管时间、丙泊酚用量和并发症发生情况。结果2组患者切皮前3 min时、手术开始20 min、术毕时OAA/S评分差异无统计学意义(P>0.05)。观察组患者术后拔管时间、自主呼吸恢复时间、苏醒时间均短于对照组,丙泊酚使用剂量少于对照组,组间比较具有统计学差异(P<0.05)。观察组恶心、呕吐、头晕等不良反应发生率均显著低于对照组(P<0.05)。结论老年消化道肿瘤术中行靶控输注丙泊酚能够提升麻醉效果,术后麻醉恢复时间快,安全性高,值得推广使用。Objective To explore the clinical efficacy and safety of target-controlled infusion of propofol in elderly patients with digestive tract tumors.Methods Eighty-four elderly patients with gastrointestinal cancer were enrolled in the study.They were divided into 2 groups according to the principle of digital randomization.42 patients in the control group were treated with continuous intravenous infusion of propofol.Patients in the observation group were treated with target-controlled infusion of propofol.The anesthetic effect of the 2 groups was evaluated using the modified alertness/sedation score(OAA/S)scale.The postoperative blink time,extubation time,and propofol were recorded.The amount of phenol and the incidence of complications.Results There was no significant difference in OAA/S scores between the two groups at 3 min before the incision and 20 min after surgery(P>0.05).The postoperative extubation time,spontaneous breathing recovery time,and recovery time were observed in the observation group.Compared with the control group,the dose of propofol was lower than that of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions such as nausea,vomiting and dizziness in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Target-controlled infusion of propofol in elderly patients with digestive tract tumors can improve the anesthetic effect.Postoperative anesthesia recovery time is fast and the safety is high,so it is worthy of promotion.

关 键 词：老年 消化道肿瘤 丙泊酚 靶控输注 

分 类 号：R735[医药卫生—肿瘤]