SOD2和GSTP1基因多态与宫颈癌易感性的关系  

SOD2 and GSTP1 polymorphisms in the genetic susceptibility to cervical cancer

作　　者：丁波[1] 孙玮 沈杨[1] 任慕兰[1] 王适之[3] DING Bo;SUN Wei;SHEN Yang;REN Mulan;WANG Shizhi(Department of Obstetrics and Gynecology,the Affiliated Zhongda Hospital of Southeast University,Nanjing 210009;Department of Obstetrics and Gynecology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029;School of Public Health,Southeast University,Nanjing 210009,China)

机构地区：[1]东南大学附属中大医院妇产科,江苏南京210009 [2]南京医科大学第一附属医院妇产科,江苏南京210009 [3]东南大学公共卫生学院,江苏南京210009

出　　处：《南京医科大学学报（自然科学版）》2020年第3期385-389,408,共6页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(81872684);江苏省自然科学基金(BK20171367)。

摘　　要：目的:探讨超氧化物歧化酶2(superoxide dismutase 2,SOD2)rs4880和谷胱甘肽S转移酶P1(glutathione S-transferase Pi,GSTP1)rs1695基因位点单核苷酸多态性与宫颈癌发生的关系。方法:选择经组织学确诊的汉族395例新发宫颈癌患者作为病例组,与病例组人群不存在生物学相关的465例正常人群作为对照组,利用Taqman实时荧光定量PCR技术检测基因型,Logistic回归模型计算基因型与人群罹患宫颈癌的风险比(odds ratio,OR)及其95%可信区间(95%CI)。结果:与SOD2 rs4880TT基因型比较,携带rs4880 TC基因型、CC基因型和TC/CC基因型的个体发生宫颈癌的风险分别升高15.1%、96.6%和18.7%,但差异无统计学意义(OR=1.15,95%CI:0.84~1.57,P=0.378;OR=1.97,95%CI:0.64~6.09,P=0.231;OR=1.19,95%CI:0.87~1.61,P=0.271);与GSTP1 rs1695 AA基因型相比,携带rs1695 AG、GG及AG/GG基因型的个体罹患宫颈癌的风险无明显变化(P>0.05),该位点多态性与宫颈癌关系的Meta分析也提示rs1695遗传变异与宫颈癌的发生无明显相关性。结论:SOD2 rs4880和GSTP1 rs1695基因多态性可能与宫颈癌发生无关。Objective:This study aims to investigate the relationship between gene polymorphisms of superoxide dismutase 2(SOD2)rs4880,glutathione S-transferase Pi(GSTP1)rs1695 and risk of cervical cancer.Methods:A case-control study was carried out including 395 patients with cervical cancer and 465 case-free controls during the same period.SOD2 rs4880 and GSTP1 rs1695 polymorphisms were examined by TaqMan-Probe assay method.Logistic regression model was used to calculate the odds ratio(OR)and95%confidence interval(95%CI)between population with different genotypes.Results:When compared with SOD2 rs4880 TT genotype,the rs4880 TC,CC,and TC/CC genotypes might increase cervical cancer risk by 15.1%,96.6%and 18.7%,respectively,but the differences were not statistically significant(OR=1.15,95%CI:0.84~1.57,P=0.378;OR=1.97,95%CI:0.64~6.09,P=0.231;OR=1.19,95%CI:0.87~1.61,P=0.271);Compared with the GSTP1 rs1695 AA genotype,individuals with rs1695 AG,GG and AG/GG genotypes showed no significant changes in the risk of cervical cancer(P>0.05).Further meta-analysis on the relationship between the polymorphism of GSTP1 rs1695 and cervical cancer also suggested that there was no significant correlation between the genetic variation of rs1695 and the occurrence of cervical cancer.Conclusion:The polymorphisms of SOD2 rs4880 and GSTP1 rs1695 may not be related to the risk of cervical cancer.

关 键 词：SOD2 GSTP1 多态性 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]