羧甲基化白及多糖-壳聚糖载姜黄素聚电解质复合膜的制备及其表征  

Carboxymethyl Bletilla striata polysaccharide-chitosan@curcumin polyelectrolyte complex films: Preparation and characterization

作　　者：王玉蓉 冯斌 巨佳 成黎霏 王济 顾宜 王晓娟 WANG Yu-rong;FENG Bin;JU Jia;CHENG Li-fei;WANG Ji;GU Yi;WANG Xiao-juan(Shaanxi University of Chinese Medicine,Xianyang 712046,China;State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture,Department of Pharmacy,Hospital of Stomatology,The Fourth Military Medical University,Xi’an 710032,China)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]军事口腔医学国家重点实验室,口腔疾病国家临床医学研究中心,陕西省口腔生物工程技术研究中心,空军军医大学口腔医院药剂科,陕西西安710032

出　　处：《中草药》2020年第4期978-985,共8页Chinese Traditional and Herbal Drugs

基　　金：陕西省中医管理局中医药科研课题(JCMS053)。

摘　　要：目的制备羧甲基化白及多糖-壳聚糖载姜黄素聚电解质复合膜,进行处方、制备工艺优化,并进行质量评价。方法对白及多糖进行羧甲基化修饰,羧甲基化白及多糖与壳聚糖通过静电结合形成水不溶性复合物。以姜黄素为模型药物,采用溶剂挥发法制备载药聚电解质复合膜;通过单因素和正交设计法进行处方优化,用扫描电子显微镜和显微红外光谱对复合膜的形态和结构进行表征。结果最优处方为羧甲基白及多糖117 mg,壳聚糖233 mg,甘油含量为25%,姜黄素为20 mg。平均厚度为(74.0±2.0)μm,载药量为95.41%,体外累积释放率可达93.78%。结论优化条件下制备的载药复合膜外观光滑平整,分布均匀,载药量和累积释放度良好。Objective To prepare carboxymethyl Bletilla striata polysaccharide-chitosan@curcumin(CM-BSP) polyelectrolyte complex films, optimize their preparation technology, and evaluate its quality. Methods CM-BSP was synthesized, then CM-BSP and CS formed water-insoluble complex by electrostatic bonding, the Cur-loaded polyelectrolyte complex films were prepared by a volatilization of solvent method. The formulation and preparation technology were optimized using an orthogonal design method and the morphology and structure were observed by scanning electron microscopy and fourier transform microscopic infrared spectroscopy. Results The optimal prescription was of CM-BSP 117 mg, CS 233 mg, glycerol 25%, Cur 20 mg. The mean thickness of Cur-loaded polyelectrolyte complex films was(74.0 ± 2.0) μm, drug loading capacities was 95.41%, and in vitro release rate was 93.78%. Conclusion The obtained polyelectrolyte complex films displayed an smooth exterior inspection, uniform distribution, good drug loading capacities and in vitro release rate.

关 键 词：羧甲基化 白及多糖 壳聚糖 姜黄素 聚电解质复合膜 处方优化 质量评价 溶剂挥发法 正交设计 

分 类 号：R283.6[医药卫生—中药学]