细菌在胃肠道肿瘤发生中的作用及其机制  

Role of bacteria in the development and progression of gastrointestinal tumors

作　　者：王也民 张家杰[2] 喻玮 Yemin Wang;Jiajie Zhang;Wei Yu(Department of Infectious Diseases,Tiantai County Hospital of Traditional Chinese Medicine,Taizhou 317200,Zhejiang Province,China;Department of Infectious Diseases,Zhejiang Provincial People's Hospital,People’s Hospital of Hangzhou Medical College,Hangzhou 310014,Zhejiang Province,China;State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,Zhejiang Province,China)

机构地区：[1]天台县中医院感染病科,浙江台州317200 [2]浙江省人民医院,杭州医学院附属人民医院,感染病科,浙江杭州310014 [3]浙江大学医学院附属第一医院,传染病诊治国家重点实验室,国家感染性疾病临床研究中心,感染性疾病诊治协同创新中心,浙江杭州310003

出　　处：《微生物学报》2020年第3期441-451,共11页Acta Microbiologica Sinica

基　　金：国家自然科学基金(81803589)。

摘　　要：胃肠道肿瘤具有较高的发病率和死亡率,其防治已成为重要的公共卫生问题。胃肠道内的菌群常参与机体的代谢和免疫反应,协同维持机体的平衡状态。多项研究发现消化道内细菌种类和数目的变化在胃肠道肿瘤的发生和发展中具有重要作用。细菌可通过毒力因子、生物膜、代谢产物等多种因素参与致肿瘤作用,甚至影响化疗药物的疗效,然而,细菌在肿瘤发生中的作用地位尚不明确。因此,本文对细菌致胃肠道肿瘤发生发展的机制进行综述,以期为胃肠道肿瘤的早期防治提供理论依据。The prevention and treatment for gastrointestinal tumors have become an important public health issue due to the high morbidity and mortality.Microflora in the gastrointestinal tract usually participate in the metabolism and immune response to maintain body homeostasis.Recent studies have found that a variety of bacteria in the gastrointestinal tract play an important role in the occurrence and development of gastrointestinal tumors.Bacteria could induce tumors by virulence factors,biofilm,metabolites and other factors.The efficacy of chemotherapeutic agents could be affected as well.However,the involvement of bacteria in tumorigenesis remains unclear.Therefore,this paper reviews the mechanisms of gastrointestinal tumors induced by bacteria,thereby providing the theoretical basis for early prevention and treatment.

关 键 词：毒力因子 生物膜 微生态 免疫调节 

分 类 号：R735[医药卫生—肿瘤]