胃泌素释放肽及其受体在瘢痕疙瘩中的表达和临床意义  

Expression of Gastrin Releasing Peptide and Its Receptor in Keloid

作　　者：崔婧博 元星花 李周娜 金承龙[1] 金珊[1] 金哲虎[1] CUI Jingbo;YUAN Xinghua;LI Zhouna;JIN Chenglong;JIN Shan;JIN Zhehu(Department of Dermatology,Yanbian University Hospital,Yanji 133000,China)

机构地区：[1]延边大学附属医院皮肤科,吉林延吉133000

出　　处：《中国皮肤性病学杂志》2020年第4期398-400,共3页The Chinese Journal of Dermatovenereology

基　　金：吉林省教育厅科研项目(JJKH20191148KJ);延边大学科研项目[延大科合字(2018)38号].

摘　　要：目的研究瘢痕疙瘩内胃泌素释放肽(GRP)及其受体(GRPR)的表达,探讨其在瘢痕疙瘩中的作用。方法使用蛋白质印迹分析检测瘢痕疙瘩及正常皮肤组织内的GRP含量,实时定量PCR检测瘢痕疙瘩及正常成纤维细胞上的GRPR表达。结果瘢痕疙瘩的GRP及GRPR表达均较正常表达升高,差异有统计学意义(P<0.05)。结论瘢痕疙瘩的GRP及GRPR过表达可能在瘢痕疙瘩的发生发展过程中有重要作用。Objective To investigate the expression and mechanism of gastrin releasing peptide(GRP) and its receptor(GRPR) in keloid. Methods Western blot was used to detect the expression of GRP in keloid and normal skin.Real-time PCR was used to detect the expression of GRPR on keloid fibroblasts and normal fibroblasts.Results The expression of GRP and GRPR in keloid was significantly higher than that in normal skin(P<0.05).Conclusion GRP and GRPR overexpression in keloid may play an important role in the pathogenesis of keloid.

关 键 词：瘢痕疙瘩 胃泌素释放肽 胃泌素释放肽受体 神经肽 

分 类 号：R739.5[医药卫生—肿瘤]