中药泡浴联合蓝光照射治疗新生儿病理性黄疸疗效分析  

Efficacy and safety of Yinchenhao Decoction combined with blue light irradiation in the treatment of neonatal pathological jaundice

作　　者：戴方娣 邵海珍 Dai Fangdi;Shao Haizhen(Department of Neonatology,Zhoushan Maternal and Child Health Care Hospital,Zhoushan,Zhejiang 316000,China;Department of Obstetrics and Gynecology,the Maternal and Child Health Care Hospital of Zhoushan,Zhoushan,Zhejiang 316000,China)

机构地区：[1]舟山市妇幼保健医院新生儿科,浙江省316000 [2]舟山市妇幼保健医院妇产科,浙江省316000

出　　处：《中国基层医药》2020年第5期559-562,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省舟山市卫生和计划生育委员会科技计划项目(2016B14)。

摘　　要：目的观察中药泡浴联合蓝光照射治疗新生儿病理性黄疸的疗效和安全性。方法选取舟山市妇幼保健医院2018年1-10月收治的新生儿病理性黄疸94例,采用随机数字表法分为对照组、观察组各47例。对照组在常规治疗基础上行蓝光照射治疗,观察组在对照组基础上联合茵陈蒿汤加减泡浴治疗,两组疗程均为7 d。比较两组治疗前后总胆红素(TBIL)、非结合胆红素(UCB)、总胆汁酸(TBA)、超敏C-反应蛋白(HS-CRP)和β-葡萄糖醛酸苷酶(β-GD)水平变化及临床疗效、不良反应发生率。结果治疗7 d后,观察组TBIL、UCB、TBA、HS-CRP分别为(116.4±6.9)μmol/L、(153.6±8.2)μmol/L、(8.3±1.3)μmol/L、(4.9±0.6)mg/L,均低于对照组的(153.6±8.2)μmol/L、(249.3±42.3)μmol/L、(25.9±2.9)μmol/L、(18.3±0.5)mg/L(t=15.851、20.329、9.624、7.508,均P<0.05);两组治疗前后β-GD均降低,观察组下降更明显(P<0.05)。观察组总有效率为97.9%(46/47),明显高于对照组的85.1%(40/47);观察组不良反应发生率为4.3%(2/47),明显低于对照组的29.8%(17/47),两组差异均有统计学意义(χ^2=11.562、14.605,均P<0.01)。结论中药泡浴联合蓝光照射治疗新生儿病理性黄疸疗效确切,不良反应发生率低。Objective To explore the efficacy and safety of Yinchenhao Decoction combined with blue light irradiation in the treatment of neonatal pathological jaundice.Methods From January 2018 to October 2018,a total of 94 neonates with pathological jaundice admitted to our hospital were divided into the control group and the observation group,with 47 cases in each group.On the basis of conventional treatment,the control group was given blue light irradiation treatment,while the observation group was treated with Yinchenhao Decoction on the basis of the control group.The changes of TBIL,UCB,TBA and HS-CRP levels,β-GD levels,clinical efficacy and incidence of adverse events were compared between the two groups after 7 days of treatment.Results After 7 days of treatment,the TBIL,UCB,TBA and HS-CRP levels in the observation group were(116.4±6.9)μmol/L,(153.6±8.2)μmol/L,(8.3±1.3)μmol/L,(4.9±0.6)mg/L,respectively,which were lower than those in the control group[(153.6±8.2)μmol/L,(249.3±42.3)μmol/L,(25.9±2.9)μmol/L,(18.3±0.5)mg/L](t=15.851,20.329,9.624,7.508,all P<0.05).Theβ-GD level reduced more significant in the observation group,which in both two groups were decreased after treatment(all P<0.05).The total effective rate of the observation group was 97.9%(46/47),which was significantly higher than that of the control group[85.1%(40/47)],and the total incidence of adverse reactions in the observation group was 4.3%(2/47),which was significantly lower than that in the control group[29.8%(17/47)],the differences were statistically significant(χ^2=11.562,14.605,all P<0.01).Conclusion Yinchenhao Decoction combined with blue light irradiation is effective in the treatment of neonatal pathological jaundice,possibly by affectingβ-GD levels.In addition,it can significantly reduce the incidence of adverse reactions in children,with better efficacy and higher safety.It is worthy of clinical reference and promotion.

关 键 词：黄疸 新生儿 中草药 浴疗学 色光疗法 胆红素 胆汁酸类和盐类 C反应蛋白质 醛脱氢酶 对比研究 

分 类 号：R722[医药卫生—儿科]