人脐带间充质干细胞用于衰老相关疾病治疗的研究进展  

Research progress of aging-related diseases treatment of human umbilical cord mesenchymal stem cells

作　　者：郑舒丹 李孟森 柳华[3] 董亚兵 程诗萌 金亮 刘志飞[5] 朱宁文 Zheng Shudan;Li Mengsen;Liu Hua;Dong Yabing;Cheng Shimeng;Jin Liang;Liu Zhifei;Zhu Ningwen(Department of Dermatology,Huashan Hospital,Fudan University,Shanghai 200040,China;Hainan Provincial Key Laboratory of Tumorogenesis and Intervention,Haikou 570100,China;Basic Medical College,Zhejiang University,Hangzhou 310058,China;China Pharmaceutical University Graduate College,Nanjing 210009,China;Department of Plastic Surgery,Peking Union Medical College Hospital,Beijing 100730,China)

机构地区：[1]复旦大学附属华山医院皮肤科,上海200040 [2]海南省肿瘤发生与干预重点实验室,海口570100 [3]浙江大学基础医学院,杭州310058 [4]中国药科大学研究生院,南京210009 [5]中国医学科学院北京协和医院整形外科,100730

出　　处：《中华整形外科杂志》2020年第2期205-210,共6页Chinese Journal of Plastic Surgery

基　　金：国家863计划(2014AA020705);上海市科委科技创新行动计划(19441909900)。

摘　　要：随着干细胞移植技术的发展,通过输入干细胞进行抗衰老治疗或治疗退行性疾病成为人们研究的热点。人脐带间充质干细胞(human umbilical cord mesenchymal stem cells,HUCMSCs)是一种存在于脐带沃顿胶以及血管周围组织中的独特前体细胞,具有自我更新和多向分化潜能。目前大量科学研究显示HUCMSCs通过再生和修复衰老的细胞、组织和器官达到抗衰老作用。该文对HUCMSCs的生物学特性、组织再生修复作用和抗衰老治疗机制的研究进展进行了详细回顾,并对目前HUCMSCs临床前研究现况进行了总结,提示HUCMSCs是一种具有良好应用潜力和价值的干细胞类型。With the development of stem cell transplantation technology,anti-aging treatment or treatment of degenerative diseases through the input of stem cells has become a research hotspot.Human umbilical cord mesenchymal stem cells(HUCMSCs)are unique precursor cells which are derived from Wharton’s jelly and the perivascular tissue of umbilical cord.They have been identified to be self-renewal and multi-differentiation potential.Currently,a large number of scientific studies have shown that HUCMSCs can achieve anti-aging effects by regenerating and repairing senescent cells,tissues and organs.This article reviews the research advances in biological characteristics,tissue regeneration and repair mechanisms,and anti-aging treatment mechanisms of HUCMSCs in detail.Besides,the current status of preclinical research on HUCMSCs is summarized,suggesting that HUCMSCs is a type of stem cell therapy with good potential and value.

关 键 词：脐带 间充质干细胞 干细胞移植 抗衰老 

分 类 号：R339.38[医药卫生—人体生理学]