培美曲塞为主的化疗方案治疗中老年非霍奇金淋巴瘤回顾性分析  

Retrospective Analysis of Pemetrexed-based Chemotherapy Regimens on Mid-elderly Non-Hodgkin's Lymphoma

作　　者：温霆宇 桂琳 靳君 张维 王婷 石远凯 刘鹏 WEN Tingyu;GUI Lin;JIN Jun;ZHANG Wei;WANG Ting;SHI Yuankai;LIU Peng(Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100021,China;Department of Internal Medicine,Sanhuan Cancer Hospital,Beijing 100021,China)

机构地区：[1]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院内科,北京100021 [2]北京市朝阳区三环肿瘤医院内科,北京100021

出　　处：《肿瘤防治研究》2020年第2期119-123,共5页Cancer Research on Prevention and Treatment

基　　金：国家科技支撑计划(2014BAI09B12);中国医学科学院医学与健康科技创新工程(2016-I2M-1-001);中国癌症基金会北京马拉松基金(N011830)。

摘　　要：目的回顾性分析培美曲塞为主的化疗方案治疗中老年非霍奇金瘤患者的安全性及有效性。方法回顾性收集2016年11月至2018年10月中国医学科学院肿瘤医院收治的以培美曲塞为主的化疗方案治疗的非霍奇金淋巴瘤患者临床资料,并对相关文献进行系统性综述。结果共纳入10例非霍奇金淋巴瘤患者,7例为弥漫大B细胞淋巴瘤,2例为血管免疫母T细胞淋巴瘤,1例为结外NK/T细胞淋巴瘤。肿瘤复发或一线治疗进展后接受培美曲塞为主的化疗方案,弥漫大B细胞淋巴瘤有4例达到部分缓解,3例疾病进展,出现的不良反应主要为Ⅰ~Ⅱ度骨髓抑制及胃肠道反应。结论培美曲塞为主的化疗方案治疗弥漫大B细胞淋巴瘤患者,尤其是原发性中枢神经系统淋巴瘤,可能有一定的有效性,且安全性可控。Objective To analyze the safety and efficacy of pemetrexed-based chemotherapy on patients with mid-elderly non-Hodgkin's lymphoma.Methods We retrospectively reviewed the clinical data of patients with non-Hodgkin's lymphoma treated with pemetrexed-based chemotherapy regimen from November 2016 to October 2018 in the Cancer Hospital of Chinese Academy of Medical Sciences,and systematically reviewed the relevant literatures.Results We enrolled 10 patients with non-Hodgkin's lymphoma treated with pemetrexed-based chemotherapy:7 cases of diffuse large B-cell lymphoma,2 cases of angioimmunoblastic T cell lymphoma and one case of extranodal NK/T cell lymphoma.After tumor recurrence or progression,these patients were treated with pemetrexed-based chemotherapy.Four cases of diffuse large B-cell lymphoma reached partial remission and three cases progressed.The main adverse events were low grade myelosuppression and gastrointestinal reactions.Conclusion Pemetrexed-based chemotherapy regimen may have certain effectiveness and safety on the patients with diffuse large B-cell lymphoma,especially primary central nervous system lymphoma.

关 键 词：非霍奇金淋巴瘤 弥漫大B细胞淋巴瘤 培美曲塞 化学治疗 

分 类 号：R733.4[医药卫生—肿瘤]