胃肝样腺癌的诊治现状  

Research status of diagnosis and treatment of gastric hepatoid adenocarcinoma

作　　者：俞程彬 马贵亮[1] 毛伟征[1] YU Chengbin;MA Guiliang;MAO Weizheng(Department of General Surgery,Qingdao Clinical Medical College,Qingdao Municipal Hospital,Affiliated to Nanjing Medical University,Qingdao,Shandong 266071,P.R.China)

机构地区：[1]南京医科大学附属青岛临床医学院青岛市市立医院普外科,山东青岛266071

出　　处：《中国普外基础与临床杂志》2020年第4期515-520,共6页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的了解胃肝样腺癌(GHA)的研究现状,以期为临床诊治提供参考。方法查阅近年来国内外关于GHA研究的相关文献并进行综述。结果 GHA是一种具有腺样分化和肝细胞分化的特殊类型胃癌,在所有胃癌中发生率≤1%。GHA的组织学形态与肝细胞癌相似,常伴有血清甲胎蛋白升高,极易出现淋巴结转移和肝转移。根治性手术及化疗是其最主要的治疗方法,但即使是根治性切除后仍常见复发和转移,且目前尚无针对GHA的标准化疗方案。结论 GHA是一种恶性度较高的特殊胃癌亚型,临床进展迅速,预后差。组织病理学结果是诊断GHA的金标准。GHA治疗以手术与化疗为主的综合治疗方式,基因分子特征及靶向治疗是未来的研究方向。Objective To understand the research status of diagnosis and treatment of gastric hepatoid adenocarcinoma(GHA)in order to provide a reference for clinical.Method The relevant literatures on diagnosis and treatment of GHA at home and abroad in recent years were searched and reviewed.Results The GHA was a special type of gastric cancer with adenoid and hepatocyte differentiations,and the incidence of GHA in all gastric cancers was less than 1%.The histological morphology of GHA was similar to that of hepatocellular carcinoma,which was often accompanied by elevated serum alpha-fetoprotein and was prone to lymph node and liver metastases.The radical surgery and adjuvant chemotherapy were the most important treatment methods.However,even when the radical resection was performed,the recurrence and metastasis were still common,and there was no standard chemotherapy regimen for GHA at present.Conclusions GHA is a special subtype of gastric cancer with high malignancy,which has rapid clinical progress and poor prognosis.Pathomorphology is the gold standard for the diagnosis of GHA.The therapy of GHA is a comprehensive treatment based on operation and chemotherapy,and gene molecular characteristics and targeted therapy are the research directions in future.

关 键 词：胃肝样腺癌 病理学特征 治疗 预后 

分 类 号：R735.2[医药卫生—肿瘤]