PI3K/Akt通路对黑色素生成的调控作用研究进展  

作　　者：王歆悦 易仁鑫 熊非[1] 

机构地区：[1]生物电子学国家重点实验室,江苏省生物材料与器件实验室,生物科学与医学工程学院,东南大学,江苏南京210000 [2]东南大学医学院第二临床学院(东部战区总医院),江苏南京210000

出　　处：《科学技术创新》2020年第7期17-18,共2页Scientific and Technological Innovation

摘　　要：黑色素广泛分布在诸多器官之中,决定人类的皮肤、头发、眼睛颜色。黑色素能够保护皮肤免受紫外线的伤害,但过量的黑色素也会造成雀斑、黄褐斑,甚至黑色素瘤等疾病。黑素生成的过程涉及一系列复杂的化学催化反应。磷脂酰肌醇3激酶(PI3K)/丝氨酸-苏氨酸激酶(Akt)通路对黑色素生成有着调控作用,但调控机制尚不明确。该文综述了PI3K/Akt通路对黑色素生成的调控作用的研究进展。Melanin is widely distributed in many organs and determines the color of human skin,hair and eyes.Melanin is a double-edged sword,which can protect skin from ultraviolet rays.But excessive melanin synthesis can also cause freckles,chloasma,even melanoma and other diseases.The process of melanogenesis involves a series of complex enzymatic and chemical reactions.Phosphatidylinositol 3 kinase(PI3K)/serine threonine kinase(Akt)signaling pathway plays a regulatory role in melanin production,but the specific regulatory mechanism is not clear.This paper reviews the research progress of the regulation of PI3K/Akt signaling pathway on melanin production.

关 键 词：黑色素 PI3K/AKT 信号通路 黑素生成 调控机制 

分 类 号：R739.5[医药卫生—肿瘤]