皂角籽中总黄酮的体内抗氧化作用研究  

Study on Antioxidation of Total Flavonoids in Gleditsia Sinensis Seeds in Vivo

作　　者：冯洁[1] 杨敏[1] 杨立轩 韦妮[1] 黄继杰[1] 莫庸[1] 凌秀孟 周世友[1] 黄锁义[1,2] FENG Jie;YANG Min;YANG Lixuan;WEI Ni;HUANG Jijie;MO Yong;LING Xiumeng;ZHOU Shiyou;HUANG Suoyi(College of Pharmacy,Youjiang Medical University for Nationalities,Baise 533000,China;Key Laboratory of Guangxi’s Colleges for The Study of Characteristic Ethnic Medicine in Youjiang River Basin,Youjiang Medical University for Nationalities,Baise 533000,China)

机构地区：[1]右江民族医学院,广西百色533000 [2]右江民族医学院广西高校右江流域特色民族药研究重点实验室,广西百色533000

出　　处：《化工技术与开发》2020年第4期5-7,共3页Technology & Development of Chemical Industry

基　　金：国家级大学生创新创业训练计划立项基金资助项目(201710599010);国家中医药管理局“十二五”中医药重点学科中药化学建设项目(国中医药人教发[2012]32号);右江民族医学院高层次人才科研项目(01002018079)。

摘　　要：将皂角籽的95%乙醇黄酮提取物设为低、中、高3个剂量,阳性组、正常组,给小鼠每天灌胃1次,连续14d。末次给药后,眼球取血,摘除肝脏和脑。探讨皂角籽中的总黄酮在小鼠体内的抗氧化活性。结果表明,与正常组相比,高剂量的皂角籽总黄酮提取物能提高小鼠体内的T-SOD、CAT、GSH-Px的活性,降低MDA水平,表明皂角籽总黄酮提取物具有较好的抗氧化作用。The 95%ethanol flavonoid extract of gleditsia sinensis seeds was set as low,medium and high doses,and mice were given intragastric administration once a day for 14 days.After the last administration,blood was taken from the eyeball and the liver and brain were removed,the antioxidant activity of total flavonoids in Gleditsia seed in mice was investigated.The results showed that compared with the normal group,the high-dose total flavonoids extract of gleditsia seed could improve the activity of T-SOD,CAT,GSH PX and reduce the level of MDA in mice,which indicated that the total flavonoids extract of gleditsia seed had better antioxidant effect.

关 键 词：皂角籽 总黄酮 体内 抗氧化活性 总超氧化物歧化酶 丙二醛 

分 类 号：R284.2[医药卫生—中药学]