TLR-4 与蛛网膜下腔出血早期脑损伤炎症反应的研究进展  

The research progress of TLR-4 and inflammatory response in early brain injury after subarachnoid hemorrhage

作　　者：王争地 尹浩 Wang Zhengdi;Yin Hao(Guizhou Medical University Guiyang,Guizhou,550000;Guizhou Provincial People's Hospital,Guiyang,Guizhou 550000,China)

机构地区：[1]贵州医科大学,贵州贵阳550000 [2]贵州省人民医院,贵州贵阳550000

出　　处：《医药前沿》2020年第4期16-17,共2页Journal of Frontiers of Medicine

基　　金：贵州省科技厅资助项目(黔科合LH字[2015]7153号)。

摘　　要：Toll样受体(TLRs)是参与非特异性免疫的一类重要蛋白质分子,同时,也是连接非特异性免疫和特异性免疫的桥梁。在中枢神经系统疾病中,免疫炎症反应对脑组织有损害作用。其中,作为TLRs的一种,TLR-4在中枢神经系统内广泛表达,蛛网膜下腔出血后各种内源性配体释放,可与TLR-4结合通过信号级联传导,参与早期脑损伤免疫炎症反应的病理生理过程。Toll Iike receptors(TLRs)are a kind of important protein molecules involved in nonspecific immunity in central nervous system diseases,the immune infammatory response to brain tissue has an important role in damage.Among them,as a kind of TLRs,TLR-4 is widely expressed in the central nervous system.After subarachnoid hemorrhage,various endogenous ligand are released,which can bind to TLR-4 through signal cascade conduction and participate in the pathophysiological process of immune inflammatory response in early brain injury.

关 键 词：TLR-4 蛛网膜下腔出血 早期脑损伤 炎症反应 

分 类 号：R743[医药卫生—神经病学与精神病学]