经导管动脉栓塞化疗联合冷循环微波消融治疗原发性肝癌的远期随访研究  

Long-term follow-up research on efficacy of transcatheter arterial chemoembolization in combination with cryoablation for primary hepatocellular carcinoma

作　　者：徐超 王媛 贾秀青 刘晓英 尹雯 冯庆亮 XU Chao;WANG Yuan;JIA Xiuqing;LIU Xiaoying;YIN Wen;FENG Qingliang(Department of Oncology,Cancer Prevention and Treatment Hospital of Liaocheng,Liaocheng 252000,Shandong,China;Department of Gastroenterology,Yantai Affiliated Hospital of Binzhou Medical College,Yantai 264117,Shandong,China)

机构地区：[1]聊城市肿瘤防治院肿瘤科,山东聊城252000 [2]滨州医学院烟台附属医院消化内科,山东烟台2641170

出　　处：《癌症进展》2020年第6期614-617,共4页Oncology Progress

摘　　要：目的探讨经导管动脉栓塞化疗(TACE)联合冷循环微波消融治疗原发性肝癌的远期疗效。方法根据治疗方式的不同将73例原发性肝癌患者分为对照组(仅行TACE治疗)39例和联合组(行冷循环微波消融联合TACE治疗)34例,比较两组患者的术后生存、局部复发和远处转移情况。结果截至随访结束,联合组与对照组患者的术后1、2年生存率比较,差异均无统计学意义(P﹥0.05);联合组患者的术后3年生存率高于对照组,中位生存时间长于对照组(P﹤0.05)。两组患者的术后1年局部复发率比较,差异无统计学意义(P﹥0.05);联合组患者的术后第2、3年局部复发率均低于对照组(P﹤0.05)。两组患者的第1、2、3年远处转移率比较,差异均无统计学意义(P﹥0.05)。结论对于原发性肝癌患者,冷循环微波消融联合TACE对于提高生存率、延长生存时间、降低局部复发率均具有一定作用。Objective To investigate the long-term efficacy of transcatheter arterial chemoembolization(TACE)in combination with cryoablation for primary hepatocellular carcinoma(HCC).Method The clinical data of 73 cases with primary HCC were retrospectively collected;according to the treatment regimens,these patients were divided into control group(receiving only TACE,n=39)or combination therapy group(receiving TACE in combination with cryoablation,n=34).The postoperative survival,local recurrence and distant metastasis were compared between the two groups.Result As of the end of follow-up,there were no significant differences between the two groups in terms of post-operative 1-year and 2-year survival rates(P>0.05);the 3-year survival rate of the combination therapy group was significantly higher than that in control group(P<0.05).Longer median survival time was observed in combination therapy group versus control group(P<0.05).No significant differences were noted between the two groups withregard to post-operative 1-year local recurrence rate(P>0.05);while the 2-year and 3-year local recurrence rates in combination therapy group was evidently lower than that in control group(P<0.05).The two groups of patients were of similar 1-,2-and 3-year distant metastasis rates(P>0.05).Conclusion The combination therapy of cryoablation and transcatheter arterial chemoembolization attaches great importance to improving the survival rate,prolonging survival time and reducing the local recurrence rate for patients with primary HCC.

关 键 词：冷循环微波消融 经导管动脉栓塞化疗 原发性肝癌 生存 复发 远处转移 

分 类 号：R735.7[医药卫生—肿瘤]