原发性食管小细胞癌的研究及诊疗现状  

Research and Clinical Diagnosis and Treatment of Primary Esophageal Small Cell Carcinoma

作　　者：吴晓 杨海军 高社干 周福有 张灏 WU Xiao;YANG Hai-jun;GAO She-gan;ZHOU Fu-you;ZHANG Hao(Cancer Research Center of Medical College,Shantou University,Shantou 515041,China;Anyang Cancer Hospital,The Fourth Affiliated Hospital of Henan University of Science and Technology,Anyang 455000,China;Institute of Cancer Research,The First Affiliated Hospital,and College of Clinical Medicine of Henan University of Science and Technology,Luoyang 471023,China;Institute of Precision Cancer Medicine and Pathology of Medical College,Jinan University,Guangzhou 510632,China)

机构地区：[1]汕头大学医学院肿瘤研究中心,广东汕头515041 [2]安阳市肿瘤医院,河南科技大学第四附属医院,河南安阳455000 [3]河南科技大学医学院,临床医学院,河南科技大学第一附属医院,河南科技大学肿瘤研究所,河南洛阳471002 [4]暨南大学肿瘤精准医学和病理研究所,广东广州510632

出　　处：《食管疾病》2020年第1期8-12,共5页Journal of Esophageal Diseases

基　　金：国家自然科学基金面上项目(81773087);广东省省级科技计划项目(2019A030317024)。

摘　　要：总结原发性食管小细胞癌的发病机制、临床病理特征、诊断、治疗现状及预后。利用关键词汇检索在https://www.ncbi.nlm.nih.gov/pubmed/及https://www.cnki.net上发表的相关文献,再融汇成文。原发性食管小细胞癌是一种少见、高侵袭、转移早、预后差、临床特征非特异的致死性恶性肿瘤。病理诊断为其唯一金标准。目前没有大规模的病例随机对照研究,其发病机制未明,治疗手段滞后。传统的治疗模式不能有效提高其生存期,而肿瘤免疫微环境、免疫治疗及靶点新药开发等研究,将是治疗原发性食管小细胞癌的新希望。To summarize the pathogenesis,clinicopathological features,diagnosis,treatment modality and prognosis of primary esophageal small cell carcinoma(PESCC).The key words were used to retrieve the relevant archives of PESCC which were collected by https://www.ncbi.nlm.nih.gov/pubmed/or https://www.cnki.net,and the data were integrated into an article.PESCC is a rare but lethal malignancy with high aggressiveness,early metastasis,poor prognosis and non-specific clinical characteristics.Pathological diagnosis is the only gold standard for confirming PESCC.Hitherto,there is no large-scale case-control studies on PESCC,so the pathogenesis of PESCC remains unknown and its treatment strategies are out of date.Traditional treatment approach cannot effectively improve patients′survival,but the study of tumor immune microenvironment,immunotherapy and new targeted drug development will be the new alternatives to treat PESCC.

关 键 词：食管肿瘤 小细胞癌 诊断 治疗 预后 

分 类 号：R735.1[医药卫生—肿瘤]